Acetic acid (Z)-1-(1,1-difluoro-2-oxo-2-pyrrolidin-1-yl-ethyl)-but-2-enyl ester | 865763-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Acetic acid (Z)-1-(1,1-difluoro-2-oxo-2-pyrrolidin-1-yl-ethyl)-but-2-enyl ester
• CAS: 865763-27-5
• 化学式: C₁₂H₁₇F₂NO₃
• 分子量: 261.269
• InChiKey: NOTFAMODBZXYBB-UTCJRWHESA-N

物化性质

• 沸点：
  380.6±42.0 °C(Predicted)
• 密度：
  1.195±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  Acetic acid (Z)-1-(1,1-difluoro-2-oxo-2-pyrrolidin-1-yl-ethyl)-but-2-enyl ester 在 磷脂酶B 作用下， 以 phosphate buffer 为溶剂， 反应 24.0h， 生成 (R)-N-((Z)-2,2-difluoro-3-hydroxy-4-hexenoyl)pyrrolidine 、 Acetic acid (Z)-(S)-1-(1,1-difluoro-2-oxo-2-pyrrolidin-1-yl-ethyl)-but-2-enyl ester
  参考文献：
  名称：

  Synthesis of stereocontrolled α,α-difluoro-β-hydroxycarbonyl materials

  摘要：

  Synthesis and synthetic utilities of stereocontrolled alpha, alpha-di fluoro-beta-hydroxy-gamma,delta-unsaturated carbonyl compounds via enzymatic resolution with lipase PS (Pseudomonas cepacia, Amano Pharmaceutical Co. Ltd.) or lipase MY (Candida rugosa, Meito Sangyo Co. Ltd.) were described, and then the absolute configuration of obtained chiral materials was determined by the modified Mosher's method. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2004.09.026
• 作为产物：
  描述：

  (Z)-2,2-Difluoro-3-hydroxy-hex-4-enoic acid ethyl ester 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 Acetic acid (Z)-1-(1,1-difluoro-2-oxo-2-pyrrolidin-1-yl-ethyl)-but-2-enyl ester
  参考文献：
  名称：

  Synthesis of stereocontrolled α,α-difluoro-β-hydroxycarbonyl materials

  摘要：

  Synthesis and synthetic utilities of stereocontrolled alpha, alpha-di fluoro-beta-hydroxy-gamma,delta-unsaturated carbonyl compounds via enzymatic resolution with lipase PS (Pseudomonas cepacia, Amano Pharmaceutical Co. Ltd.) or lipase MY (Candida rugosa, Meito Sangyo Co. Ltd.) were described, and then the absolute configuration of obtained chiral materials was determined by the modified Mosher's method. (C) 2004 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2004.09.026