PcSi(OH)2 | 957486-41-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: PcSi(OH)2
• 英文别名: Dihydroxo(tetra-t-butylphthalocyaninato)-silicium；dihydroxy(tetra-tert-butylphthalocyaninato)silicon；dihydroxy{2,9,16,23-tetra-tert-butylphthalocyaninato}silicon；PcSi(OH)₂
• CAS: 957486-41-8
• 化学式: C₄₈H₅₀N₈O₂Si
• 分子量: 799.063
• InChiKey: YTJFELPKNFDSGI-ONAHWTHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.55
• 重原子数：
  59.0
• 可旋转键数：
  0.0
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  124.48
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  PcSi(OH)2 在 喹啉 作用下， 反应 1.33h， 以17.6%的产率得到μ-oxo-bis[hydroxy{2,9,16,23-tetra-tert-butylphthalocyaninato}silicon]
  参考文献：
  名称：

  Synthesis and Characterization of Phthalocyanines with Direct Si−Si Linkages

  摘要：

  Several cofacial phthalocyanines (Pcs) with an Si-Si linkage were obtained by one-step condensation of 1H-isoindole-1.3(2H)-diimine with hexachlorodisilane as template in quinoline. They were characterized by gel-permeation chromatography, IR, NMR spectroscopy, and mass spectrometry, and cyclic voltammetry. The results strongly suggest that we indeed obtained Pc dimers directly linked by an Si-Si bond using this novel concept of utilizing a compound/salt with an element-clement bond as a template. The cofacial dimer structures are reasonably supported by X-ray absorption near-edge structure (XANES), electronic absorption and magnetic circular dichroism (MCD) spectra, and molecular orbital (MO) calculations. interestingly, they show an electronic absorption spectrum very similar to that of silicon tetrabenztriazacorrole (SiTBC).

  DOI：

  10.1002/1521-3765(20020315)8:6<1474::aid-chem1474>3.0.co;2-p
• 作为产物：
  描述：

  dichloro(tetra-tert-butylphthalocyaninato)silicon 在 吡啶 、 ammonium hydroxide 作用下， 反应 24.0h， 生成 PcSi(OH)2
  参考文献：
  名称：

  Metz, Josef; Pawlowski, Georg; Hanack, Michael, Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1983, vol. 38, # 3, p. 378 - 382

  摘要：

  DOI：

文献信息

• A Multifunctional Theranostic Platform Based on Phthalocyanine-Loaded Dendrimer for Image-Guided Drug Delivery and Photodynamic Therapy
  作者：Olena Taratula、Canan Schumann、Michael A. Naleway、Addison J. Pang、Kaitlyn J. Chon、Oleh Taratula

  DOI：10.1021/mp400397t

  日期：2013.10.7

  fluorescence imaging. It was demonstrated that subcellular localization in vitro and organ distribution in vivo of the developed nanocarrier can be determined based on the intrinsic fluorescence properties of encapsulated phthalocyanine, validating its role as an imaging agent. The imaging experiments revealed that the LHRH targeted nanocarrier is capable of an efficient internalization into cancer cells as

  由于其出色的近红外（NIR）光学特性，酞菁（Pc）具有治疗前景，有望成为荧光成像引导药物递送和通过光动力疗法（PDT）进行无创治疗的治疗试剂。然而，酞菁的临床应用受到水溶性差，聚集和对癌细胞选择性不足的限制。为了解决这些问题，我们开发了一种新颖的基于树枝状大分子的治疗药物平台，可用于肿瘤靶向的酞菁类药物的递送。制备过程涉及用疏水性连接基修饰Pc分子，这大大增强了疏水性药物在第4代聚丙烯亚胺（PPI G4）树状大分子中的物理包封。为了改善生物相容性和肿瘤靶向递送，分别用聚乙二醇（PEG）和促黄体激素释放激素（LHRH）肽修饰所得Pc-PPIG4复合物的表面。所开发的纳米载体的平均直径为62.3 nm，粒度分布较窄，多分散指数为0.100。药物的包封效率为20％w / w，并且嵌入在基于树枝状聚合物的纳米载体中的合成酞菁衍生物表现出独特的NIR吸收（700 nm）和荧光发射（710和815 n
• Gale, David C.; Gaudiello, John G., Journal of the American Chemical Society, 1991, vol. 113, # 5, p. 1610 - 1618
  作者：Gale, David C.、Gaudiello, John G.

  DOI：——

  日期：——