(Z)-4-fluoro-N'-(1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethylidene)benzohydrazide | 948840-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-4-fluoro-N'-(1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethylidene)benzohydrazide
• 英文别名: (E)-4-fluoro-N'-(1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethylidene)benzohydrazide；4-fluoro-N-[(Z)-1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]ethylideneamino]benzamide
• CAS: 948840-45-7
• 化学式: C₁₆H₁₉FN₄O₅
• 分子量: 366.349
• InChiKey: OQMHKSXAVUYMIY-QHKRPNGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  151
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• Imidazole-based compounds, compositions comprising them and methods of their use
  申请人：Augeri J. David

  公开号：US20070208063A1

  公开（公告）日：2007-09-06

  Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:

  基于咪唑的化合物、包含它们的组合物以及它们用于治疗、预防和管理炎症性和自身免疫性疾病和紊乱的方法被披露。特定的化合物具有如下式I：
• COMPOSITIONS AND METHODS FOR TREATING IMMUNOLOGICAL AND INFLAMMATORY DISEASES AND DISORDERS
  申请人：Oravecz Tamas

  公开号：US20090068180A1

  公开（公告）日：2009-03-12

  Methods and compositions for treating immunological and inflammatory diseases and disorders are disclosed. Particular methods and compositions comprise the administration of an agent that inhibits S1P lyase activity and at least one additional immunosuppressive and/or anti-inflammatory agent.

  揭示了用于治疗免疫和炎症性疾病和紊乱的方法和组合物。特定的方法和组合物包括给予抑制S1P裂解酶活性的药物以及至少一种额外的免疫抑制和/或抗炎药物。
• Imidazole based compounds, compositions comprising them and methods of their use
  申请人：Lexicon Pharmaceuticals, Inc.

  公开号：EP2090334A2

  公开（公告）日：2009-08-19

  Inudazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:

  本发明公开了以Inudazole为基础的化合物、包含它们的组合物以及它们用于治疗、预防和控制炎症性和自身免疫性疾病和紊乱的方法。具体化合物如式 I 所示：
• COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE MUSCLE CONDITIONS
  申请人：University of Washington

  公开号：US20140051729A1

  公开（公告）日：2014-02-20

  Methods and compositions for treating degenerative muscle conditions are disclosed. The compositions disclosed herein include S1P promoting compositions that include an S1P promoting agent. Embodiments of the methods disclosed herein include administering therapeutically effective amounts to subjects suffering from a degenerative muscle condition, such as, for example, subjects suffering from sarcopenia and subjects suffering from muscular dystrophy, including subjects suffering from Duchenne Muscular Dystrophy and Becker Muscular Dystrophy.
• US7825150B2
  申请人：——

  公开号：US7825150B2

  公开（公告）日：2010-11-02