[((R)-6,6'-1,1'-binaphth-2-olato)2Zr(N-methylimidazole)2] | 201339-16-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [((R)-6,6'-1,1'-binaphth-2-olato)2Zr(N-methylimidazole)2]
• CAS: 201339-16-4
• 化学式: C₄₈H₃₂Br₄N₄O₄Zr
• 分子量: 1139.65
• InChiKey: AUMIKPADMTYDPT-UHFFFAOYSA-J

反应信息

• 作为产物：
  描述：

  N-甲基咪唑 、 zirconium(IV) tert-butoxide 、 (S)-6,6'-dibromo-1,1'-binaphthalene-2,2'-diol 以 not given 为溶剂， 生成 [((R)-6,6'-1,1'-binaphth-2-olato)2Zr(N-methylimidazole)2]
  参考文献：
  名称：

  在使用手性锆催化剂的情况下，Imino Dienophiles的第一个对映选择性Aza-Diels-Alder反应。

  摘要：

  手性二氢吡啶酮衍生物3可通过醛亚胺（如1）与Danishefsky's diene 2的标题反应以高收率和良好的对映选择性得到。6,6'-Dibromo-1,1'-binaphthol配合物与第4组金属配合使用；锆被证明是特别有效的。

  DOI：

  10.1002/(sici)1521-3773(19980420)37:7<979::aid-anie979>3.0.co;2-5

文献信息

• Active Site Design in a Chemzyme: Development of a Highly Asymmetric and Remarkably Temperature-Independent Catalyst for the Imino Aldol Reaction
  作者：Song Xue、Su Yu、Yonghong Deng、William D. Wulff

  DOI：10.1002/1521-3773(20010618)40:12<2271::aid-anie2271>3.0.co;2-n

  日期：2001.6.18

  Unusually robust: A remarkably temperature-independent catalyst has been developed for the imino aldol reaction of imines derived from ortho-aminophenols. This catalyst is prepared from two equivalents of the VAPOL ligand and a zirconium tetraalkoxide. From a consideration of likely intermediates in the catalytic cycle it was deduced that a methyl substituent ortho to the phenol (R1 ) should enhance induction. This resulted in asymmetric inductions in excess of 98 % ee at room temperature as well as at 100°C. TMS=trimethylsilyl.