Oligomycin a, b, c mixture

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: Oligomycin a, b, c mixture
• 英文别名: (4E,18E,20Z)-22-ethyl-7,11,14,15-tetrahydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione
• 化学式: C₄₅H₇₄O₁₁
• 分子量: 791.1
• InChiKey: MNULEGDCPYONBU-ZUSSGZTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  56
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  180
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• Pathway Analysis of Cell Culture Phenotypes and Uses Thereof
  申请人：Melville Mark

  公开号：US20090186358A1

  公开（公告）日：2009-07-23

  The present invention provides methods for systematically identifying genes, proteins and/or related pathways that regulate or indicative of cell phenotypes. The present invention further provides methods for manipulating the identified genes, proteins and/or pathways to engineer improved cell lines and/or to evaluate or select cell lines with desirable phenotypes.
• [EN] LIQUID FORMULATION, IN PARTICULAR TO TREAT A CORNEAL TISSUE<br/>[FR] FORMULATION LIQUIDE, EN PARTICULIER POUR TRAITER UN TISSU CORNÉEN
  申请人：VISION ENG ITALY SRL

  公开号：WO2021009623A1

  公开（公告）日：2021-01-21

  Liquid formulation including a photo-sensitizing agent and an oxidizing agent, in particular for the treatment of eye disorders.
• [EN] METHODS AND COMPOSITIONS FOR GENERATING FUNCTIONALLY MATURE BETA CELLS AND USES THEREOF<br/>[FR] MÉTHODES ET COMPOSITIONS POUR GÉNÉRER DES CELLULES BÊTA FONCTIONNELLEMENT MÛRES ET UTILISATIONS ASSOCIÉES
  申请人：UNIV WASHINGTON

  公开号：WO2021102305A1

  公开（公告）日：2021-05-27

  Among the various aspects of the present disclosure is the provision of methods and compositions for the generation of functionally mature beta cells having enhanced SIX2+ activity and therapeutic benefit and uses thereof. An aspect of the present disclosure provides for a method of generating SIX2-enhanced SC-β cells. In some embodiments, the method comprises providing a population of SC-β cells (or EP cells); providing a SIX2 positive regulator; and/or incubating the population of SC-β cells and the SIX2 positive regulator.