phenylphosphonic acid bis(2-nitrophenyl ester) | 73404-18-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenylphosphonic acid bis(2-nitrophenyl ester)
• 英文别名: bis(2-nitrophenyl) phenylphosphonate；bis(o-nitrophenyl)phenylphosphonate；1-Nitro-2-[(2-nitrophenoxy)-phenylphosphoryl]oxybenzene
• CAS: 73404-18-9
• 化学式: C₁₈H₁₃N₂O₇P
• 分子量: 400.284
• InChiKey: BBGYASXSZUVYLQ-UHFFFAOYSA-N

物化性质

• 沸点：
  556.6±50.0 °C(Predicted)
• 密度：
  1.47±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  127
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• MORPHIC FORMS OF COMPLEMENT FACTOR D INHIBITORS
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：EP3856164A1

  公开（公告）日：2021-08-04
• METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STXB) MONOMERS AND OLIGOMERS, AND USES THEREOF
  申请人：Institut Curie

  公开号：EP3980057A1

  公开（公告）日：2022-04-13
• [EN] MORPHIC FORMS OF COMPLEMENT FACTOR D INHIBITORS<br/>[FR] FORMES MORPHIQUES D'INHIBITEURS DU FACTEUR D DU COMPLÉMENT
  申请人：ACHILLION PHARMACEUTICALS INC

  公开号：WO2020069024A1

  公开（公告）日：2020-04-02

  This invention provides stable, highly crystalline forms of Complement Factor D inhibitor Compound 3 for therapeutic applications.
• [EN] METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF<br/>[FR] MÉTHODES DE PRODUCTION DE MONOMÈRES ET D'OLIGOMÈRES DE LA SOUS-UNITÉ B DE LA TOXINE DE SHIGA (STXB), ET LEURS UTILISATIONS
  申请人：INST CURIE

  公开号：WO2020245321A1

  公开（公告）日：2020-12-10

  The present invention relates to a method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods described herein are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.