Methyl 4-(4-methylthiophenyl)-3(E)-butenyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate | 99522-65-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Methyl 4-(4-methylthiophenyl)-3(E)-butenyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate
• 英文别名: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 4-(4-(methylthio)phenyl)-3-butenyl ester；3-O-methyl 5-O-[(E)-4-(4-methylsulfanylphenyl)but-3-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 99522-65-3
• 化学式: C₂₇H₂₈N₂O₆S
• 分子量: 508.595
• InChiKey: ZOUAHPQAIBNYAK-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  136
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• 1,4-dihydropyridine derivatives, methods for their production and pharmaceutical compositions comprising the same
  申请人：FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.

  公开号：EP0161877A2

  公开（公告）日：1985-11-21

  1,4-dihydropyridine derivatives having hypotensive action whose time to take effect is long so that blood pressure drops slowly, and whose toxicity is low possess the following general formula wherein specifically R3 is a combined group formed from an unsaturated straight chain hydrocarbon or derivative thereof with (1) an unsaturated hydrocarbyl group or (2) an aryl or hydroaromatic group. A carbon atom of an unsaturated group of the unsaturated hydrocarbon(s) or a ring carbon atom of the aryl or hydroaromatic group is connected to a carbon atom of an unsaturated group of the unsaturated straight chain hydrocarbon or derivative thereof.

  具有降压作用的 1,4-二氢吡啶衍生物，起效时间长，血压下降缓慢，毒性低，通式如下 其中，R3 是由不饱和直链烃或其衍生物与(1)不饱和烃基或(2)芳基或芳香族基团形成的组合基团。不饱和烃的不饱和基团的碳原子或芳基或烃基的环碳原子与不饱和直链烃或其衍生物的不饱和基团的碳原子相连。
• US5034395A
  申请人：——

  公开号：US5034395A

  公开（公告）日：1991-07-23
• US5137889A
  申请人：——

  公开号：US5137889A

  公开（公告）日：1992-08-11