(S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylacetyl-dihydro-pyrimidine-2,4-dione | 313342-74-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: (S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylacetyl-dihydro-pyrimidine-2,4-dione
• CAS: 313342-74-4
• 化学式: C₁₈H₂₂N₂O₆
• 分子量: 362.382
• InChiKey: RUHTYTCSRWZKDO-OJIVJNGMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.18
• 重原子数：
  26.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  116.17
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylacetyl-dihydro-pyrimidine-2,4-dione 生成
  参考文献：
  名称：

  Synthesis and Deprotection of Oligonucleotides under Aprotic Conditions

  摘要：

  [GRAPHICS]Oligonucleotides containing an alkali labile nucleotide are synthesized and deprotected using a synthetic method that eliminates the use of Bronsted acid and base. The development of a new family of exocyclic amine protecting groups is an integral component of this approach.

  DOI：

  10.1021/ol006604p
• 作为产物：
  描述：

  (S)-1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-5-phenylacetyl-dihydro-pyrimidine-2,4-dione 在 三氟乙酸 、 triethylamine tris(hydrogen fluoride) 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 (S)-1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-5-phenylacetyl-dihydro-pyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis and Deprotection of Oligonucleotides under Aprotic Conditions

  摘要：

  [GRAPHICS]Oligonucleotides containing an alkali labile nucleotide are synthesized and deprotected using a synthetic method that eliminates the use of Bronsted acid and base. The development of a new family of exocyclic amine protecting groups is an integral component of this approach.

  DOI：

  10.1021/ol006604p