4-[(3-sec-butoxy-4-nitrobenzoyl)amino]-3-isobutoxybenzamide | 1350897-11-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(3-sec-butoxy-4-nitrobenzoyl)amino]-3-isobutoxybenzamide
• 英文别名: 4-[(3-Butan-2-yloxy-4-nitrobenzoyl)amino]-3-(2-methylpropoxy)benzamide
• CAS: 1350897-11-8
• 化学式: C₂₂H₂₇N₃O₆
• 分子量: 429.473
• InChiKey: ZSMMSCKNYKALRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• OLIGO-BENZAMIDE COMPOUNDS AND THEIR USE
  申请人：The Board of Regents of the University of Texas System

  公开号：EP2575453B1

  公开（公告）日：2018-08-01
• OLIGO-BENZAMIDE COMPOUNDS FOR USE IN TREATING CANCERS
  申请人：The Board of Regents of the University of Texas S

  公开号：US20130184345A1

  公开（公告）日：2013-07-18

  The present invention provides bis- and tris-benzamide compounds in the treatment of breast, brain and ovarian cancers.
• OLIGO-BENZAMIDE COMPOUNDS AND THEIR USE IN TREATING CANCERS
  申请人：The Board of Regents of the University of Texas S

  公开号：US20130150442A1

  公开（公告）日：2013-06-13

  The present invention includes bis- and tris-benzamide compounds that block AR signaling and have activity against prostate cancer. Uses for these compounds, and pharmaceutical compositions containing the same, also are provided.
• US8754124B2
  申请人：——

  公开号：US8754124B2

  公开（公告）日：2014-06-17
• US8835493B2
  申请人：——

  公开号：US8835493B2

  公开（公告）日：2014-09-16