4-aminooxymethyl-benzoic acid | 628704-02-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-aminooxymethyl-benzoic acid
• 英文别名: 4-Carboxybenzyloxyamin；4-[(Aminooxy)methyl]benzoic acid；4-(aminooxymethyl)benzoic acid
• CAS: 628704-02-9
• 化学式: C₈H₉NO₃
• 分子量: 167.164
• InChiKey: OMRHFPOJOQVYRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙醇 、 4-aminooxymethyl-benzoic acid 在 盐酸 作用下， 生成 4-Carbaethoxybenzyloxyamin
  参考文献：
  名称：

  Deles,J. et al., Polish Journal of Chemistry, 1979, vol. 53, p. 1025 - 1032

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(溴甲基)苯甲酸乙酯 生成 4-aminooxymethyl-benzoic acid
  参考文献：
  名称：

  Deles,J. et al., Polish Journal of Chemistry, 1979, vol. 53, p. 1025 - 1032

  摘要：

  DOI：

文献信息

• Solid-Phase Oligosaccharide Tagging: a Technique for Manipulation of Immobilized Carbohydrates
  申请人：Lohse Anders

  公开号：US20080227092A1

  公开（公告）日：2008-09-18

  The invention relates to methods of manipulating immobilised carbohydrates by derivatisation. Depending on the nature of the derivatisation, the carbohydrate may thereby be more easily detected and/or identified or handled. In particular, the invention relates to methods of preparing a reactive sugar comprising the steps of: i) providing a sample comprising a reducing sugar; ii) providing a solid support covalently attached to a linker comprising a capture group comprising an —NH2 group, wherein said linker optionally is attached to said solid support via a spacer; iii) reacting said reducing sugar with said —NH2 group, thereby obtaining an immobilised sugar; iv) reacting free —NH2 groups with a capping agent, wherein the capping agent comprises a reactive group capable of reacting with an —NH2 group; and v) reducing C═N bonds with a reducing agent, thereby obtaining an reactive sugar of the structure SugarCH n —NH— linked to a solid support via a linker and optionally a spacer, wherein n is 1 or 2.

  本发明涉及通过衍生化来操纵固定化碳水化合物的方法。根据衍生化的性质，碳水化合物可以更容易地被检测和/或识别或处理。特别地，本发明涉及制备反应性糖的方法，包括以下步骤：i）提供包含还原糖的样品；ii）提供共价连接到捕获基团（包括—NH2基团）的连接剂的固体支持，其中所述连接剂可以通过间隔物连接到所述固体支持；iii）将还原糖与所述—NH2基团反应，从而获得固定化糖；iv）用盖帽剂反应自由—NH2基团，所述盖帽剂包括能够与—NH2基团反应的反应性基团；v）用还原剂还原C═N键，从而获得结构为SugarCHn—NH—的反应性糖，其通过连接剂和可选的间隔物与固体支持连接，其中n为1或2。
• IDO Inhibitors
  申请人：Mautino Mario

  公开号：US20110053941A1

  公开（公告）日：2011-03-03

  Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

  目前提供以下方法：(a) 通过接触本文中描述的化合物的调节有效量与吲哚胺2,3-二氧化酶相互作用，从而调节吲哚胺2,3-二氧化酶的活性；(b) 治疗需要吲哚胺2,3-二氧化酶(IDO)介导的免疫抑制的患者，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(c) 治疗需要抑制吲哚胺-2,3-二氧化酶酶活性的医疗状况，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(d) 增强抗癌治疗的有效性，包括给予抗癌剂和本文中描述的化合物；(e) 治疗与癌症相关的肿瘤特异性免疫抑制，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(f) 治疗与传染病相关的免疫抑制，例如HIV-1感染，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量。
• Respiratory syncytial virus fusion inhibitors. Part 7: Structure–activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo
  作者：Ny Sin、Brian L. Venables、Keith D. Combrink、H. Belgin Gulgeze、Kuo-Long Yu、Rita L. Civiello、Jan Thuring、X. Alan Wang、Zheng Yang、Lisa Zadjura、Anthony Marino、Kathleen F. Kadow、Christopher W. Cianci、Junius Clarke、Eugene V. Genovesi、Ivette Medina、Lucinda Lamb、Mark Krystal、Nicholas A. Meanwell

  DOI：10.1016/j.bmcl.2009.06.030

  日期：2009.8

  A series of bezimidazole-isatin oximes were prepared and profiled as inhibitors of respiratory syncytial virus (RSV) replication in cell culture. Structure-activity relationship studies were directed toward optimization of antiviral activity, cell permeability and metabolic stability in human liver micorosomes (HLM). Parallel combinatorial synthetic chemistry was employed to functionalize isatin oximes via O-alkylation which quickly identified a subset of small, lipophilic substituents that established good potency for the series. Further optimization of the isatin oxime derivatives focused on introduction of nitrogen atoms to the isatin phenyl ring to provide a series of aza-isatin oximes with significantly improved PK properties. Several aza-isatin oximes analogs displayed targeted metabolic stability in HLM and permeability across a confluent monolayer of CaCo-2 cells. These studies identified several compounds, including 18i, 18j and 18n that demonstrated antiviral activity in the BALB/c mouse model of RSV infection following oral dosing. (C) 2009 Elsevier Ltd. All rights reserved.
• Coronelli; Lancini; Pallanza, Farmaco, Edizione Scientifica, 1966, vol. 21, # 6, p. 450 - 463
  作者：Coronelli、Lancini、Pallanza、Tamoni、Sensi

  DOI：——

  日期：——
• SOLID-PHASE OLIGOSACCHARIDE TAGGING: A TECHNIQUE FOR MANIPULATION OF IMMOBILIZED CARBOHYDRATES
  申请人：Merck Patent GmbH

  公开号：EP1846765B1

  公开（公告）日：2009-05-27