4-(9H-芴)-1,3-噻唑-2-胺 | 299438-56-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 4-(9H-芴)-1,3-噻唑-2-胺
• 英文名称: 4-fluoren-2-yl-thiazol-2-ylamine
• 英文别名: 4-Fluoren-2-yl-thiazol-2-ylamin；2-Amino-4-fluoren-2-yl-thiazol；4-(9H-fluoren-2-yl)-1,3-thiazol-2-amine
• CAS: 299438-56-5
• 化学式: C₁₆H₁₂N₂S
• mdl: MFCD00806357
• 分子量: 264.351
• InChiKey: ILZSNYCMULKIOG-UHFFFAOYSA-N

物化性质

• 沸点：
  517.7±29.0 °C(Predicted)
• 密度：
  1.331±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.062
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

SDS

Name:	4-(9H-Fluoren-2-yl)-1 3-thiazol-2-amine 97% Material Safety Data Sheet
Synonym:
CAS:	299438-56-5

Section 1 - Chemical Product MSDS Name:4-(9H-Fluoren-2-yl)-1 3-thiazol-2-amine 97% Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
299438-56-5	4-(9H-Fluoren-2-yl)-1,3-thiazol-2-amin	97%	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 299438-56-5: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: beige
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 261 - 264 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C16H12N2S
Molecular Weight: 264

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents, acids, acid chlorides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide, acrid smoke and fumes.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 299438-56-5 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4-(9H-Fluoren-2-yl)-1,3-thiazol-2-amine - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 299438-56-5: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 299438-56-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 299438-56-5 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为产物：
  描述：

  2-乙酰芴 、 硫脲 在 1,4-二氧六环 、 碘 作用下， 生成 4-(9H-芴)-1,3-噻唑-2-胺
  参考文献：
  名称：

  FLUORENE DERIVATIVES FOR CANCER RESEARCH¹

  摘要：

  DOI：

  10.1021/jo01155a007

文献信息

• N-(5-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS
  申请人：Schmitz Ulrich Franz

  公开号：US20070265265A1

  公开（公告）日：2007-11-15

  Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R 2 , m, R, V, W, T, Z, R 1 , Y, and p are disclosed herein.

  揭示了具有Formula (I)的化合物，以及用于治疗或预防由Flaviviridae病毒家族中的病毒至少部分介导的病毒感染的组合物和方法，其中A、R2、m、R、V、W、T、Z、R1、Y和p在此处被揭示。
• Antiproliferative compounds and therapeutic uses thereof
  申请人：Università Degli Studi Di Milano - Bicocca

  公开号：EP2107054A1

  公开（公告）日：2009-10-07

  Inhibitors of the oncogenic tyrosine kinase ALK and of the Bcr-Abl mutant T315I Bcr-Abl, such as a compound of formula (I): wherein Q, T, W, K, J, Y, X, Z are independently selected from C, N, S, O, provided that the corresponding rings are (hetero)aromatic; n = 0 or 1; q = 1 or 2; pharmaceutical compositions containing the same and their use for the treatment of hyper-proliferative diseases.

  抑制癌基因酪氨酸激酶ALK和Bcr-Abl突变体T315I Bcr-Abl的抑制剂，例如式(I)的化合物： 其中Q、T、W、K、J、Y、X、Z分别独立选择自C、N、S、O，前提是相应的环是(杂)芳香的； n = 0或1； q = 1或2； 含有相同化合物的药物组合物及其用于治疗高增殖性疾病。
• N-(5-Membered Aromatic Ring)-Amido Anti-Viral Compounds
  申请人：Schmitz Franz Ulrich

  公开号：US20100004441A1

  公开（公告）日：2010-01-07

  Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R 2 , m, R, V, W, T, Z, R 1 , Y, and p are disclosed herein.

  本发明涉及具有式（I）的化合物及其组合物和方法，用于治疗或预防由Flaviviridae病毒家族中的病毒至少部分介导的病毒感染。其中，本文披露了A、R2、m、R、V、W、T、Z、R1、Y和p。
• ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF
  申请人：Gambacorti Passerini Carlo

  公开号：US20110112110A1

  公开（公告）日：2011-05-12

  Inhibitors of the oncogenic tyrosine kinase ALK and of the Bcr-Abl mutant T315I Bcr-Abl, pharmaceutical compositions containing the same and their use for the treatment of hyper-proliferative diseases.

  抑制癌基因酪氨酸激酶ALK和Bcr-Abl突变体T315I Bcr-Abl的抑制剂，包含它们的制药组合物以及它们用于治疗高增殖性疾病的用途。
• US7595398B2
  申请人：——

  公开号：US7595398B2

  公开（公告）日：2009-09-29