tBu(Mes)PH | 192509-29-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tBu(Mes)PH
• 英文别名: Tert-butyl-(2,4,6-trimethylphenyl)phosphane
• CAS: 192509-29-8
• 化学式: C₁₃H₂₁P
• 分子量: 208.284
• InChiKey: FRZNEWHOAKSONM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  tBu(Mes)PH 、 三(五氟苯基)硼烷 以 甲苯 为溶剂， 以64%的产率得到(t-Bu)(Mes)PH(C6F4)BF(C6F5)2
  参考文献：
  名称：

  膦与缺电子的硼烷的反应。

  摘要：

  一系列经典的B（C（6）F（5））（3）-膦加合物显示为反应性分子。（THF）B（C（6）F（5））（3）与膦的反应显示出THF的开环作用，从而得到形式为R（2）PH（C（4））的两性离子硼酸phospho盐物种H（8）O）B（C（6）F（5））（3）和R（3）P（C（4）H（8）O）B（C（6）F（5））（3 ）。或者，用磷化锂（R（2）PLi，R = tBu，Ph Mes）处理（THF）B（C（6）F（5））（3），得到[Li（THF）（ x）] [R（2）P（C（4）H（8）O）B（C（6）F（5））（3）]。此外，双THF开环也被证明可以形成[Li（THF）（x）] [R（2）P（C（4）H（8）OB（C（6）F（5）） ）（3））（2）]。此外，还显示了一系列经典的硼烷-膦加合物进行热重排反应，以得到芳香族取代基R（2）PH（C（6（F）4（4））BF（C（6）F（5））的两性离子产物。

  DOI：

  10.1039/b814486a

文献信息

• Aromatic phosphonium salts and their use as labeling reagents in mass spectrometry analysis
  申请人：Gebler C. John

  公开号：US20070087446A1

  公开（公告）日：2007-04-19

  This invention relates to methods and reagents for the assay, detection, quantification, location, or analysis of each of a plurality of substances of interest (“analytes”) in a sample in which each substance is labeled with a cationic triarylphosphonium group. The present invention also provides MALDI mass spectrometry techniques in which the analysis of samples containing low molecule weight analytes is not obscured by matrix components. The invention also provides labeling reagents for use in labeling analytes prior to MS analysis in which the labeled analytes have a molecular weight above the useful detection threshold of MALDI techniques. In some aspects, the invention provides methods of quantitative MS analysis of components of a sample. Methods of the present invention include sensitive techniques for desorption/ionization of molecules at the picomole, femtomole, and attomole amounts. Another benefit of the present invention is that measurement of m/Z values is not complicated by the low-mass interference that a matrix normally offers, and therefore the invention provides methods of MALDI MS analysis of low molecular weight samples as well as mixtures of high and low molecular weight samples.