(Z)-N'-(1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethylidene)isonicotinohydrazide | 948840-47-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (Z)-N'-(1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethylidene)isonicotinohydrazide
• 英文别名: (E)-N'-(1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethylidene)isonicotinohydrazide；N-[(Z)-1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]ethylideneamino]pyridine-4-carboxamide
• CAS: 948840-47-9
• 化学式: C₁₅H₁₉N₅O₅
• 分子量: 349.346
• InChiKey: LRDOYXUZHLWGHD-YHQUHOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  164
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• Imidazole-based compounds, compositions comprising them and methods of their use
  申请人：Augeri J. David

  公开号：US20070208063A1

  公开（公告）日：2007-09-06

  Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:

  基于咪唑的化合物、包含它们的组合物以及它们用于治疗、预防和管理炎症性和自身免疫性疾病和紊乱的方法被披露。特定的化合物具有如下式I：
• COMPOSITIONS AND METHODS FOR TREATING IMMUNOLOGICAL AND INFLAMMATORY DISEASES AND DISORDERS
  申请人：Oravecz Tamas

  公开号：US20090068180A1

  公开（公告）日：2009-03-12

  Methods and compositions for treating immunological and inflammatory diseases and disorders are disclosed. Particular methods and compositions comprise the administration of an agent that inhibits S1P lyase activity and at least one additional immunosuppressive and/or anti-inflammatory agent.

  揭示了用于治疗免疫和炎症性疾病和紊乱的方法和组合物。特定的方法和组合物包括给予抑制S1P裂解酶活性的药物以及至少一种额外的免疫抑制和/或抗炎药物。
• S1P LYASE INHIBITORS FOR THE TREATMENT OF CEREBRAL MALARIA
  申请人：Brown Philip Manton

  公开号：US20100113530A1

  公开（公告）日：2010-05-06

  Methods and compositions for treating, managing, and/or preventing cerebral malaria are disclosed.

  揭示了用于治疗、管理和/或预防脑疟疾的方法和组合物。
• METHODS OF TREATING RHEUMATOID ARTHRITIS
  申请人：Augeri David J.

  公开号：US20100076030A1

  公开（公告）日：2010-03-25

  Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:

  本发明涉及基于咪唑的化合物、包括它们的组合物，以及它们的使用方法，用于治疗、预防和管理炎症和自身免疫性疾病和障碍。特定的化合物属于I式：
• METHODS OF TREATING ULCERATIVE COLITIS
  申请人：Augeri David J.

  公开号：US20130005775A1

  公开（公告）日：2013-01-03

  Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed.

  本发明公开了使用抑制S1P裂解酶的咪唑类化合物治疗和管理溃疡性结肠炎的方法。