4-Oxo-4-(3-(1-propylpentadecyl)phenyl)-2-butenoic acid | 133800-88-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Oxo-4-(3-(1-propylpentadecyl)phenyl)-2-butenoic acid
• 英文别名: (E)-4-(3-octadecan-4-ylphenyl)-4-oxobut-2-enoic acid
• CAS: 133800-88-1
• 化学式: C₂₈H₄₄O₃
• 分子量: 428.6
• InChiKey: OLTDVZPGSDCOGR-QURGRASLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  31
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL LIPASE INHIBITORS, REPORTER SUBSTRATES AND USES THEREOF
  申请人：Northeastern University

  公开号：US20150099800A1

  公开（公告）日：2015-04-09

  The invention provides for novel lipase inhibitors, and compositions and devices comprising the same. The invention further provides for methods for treatment of disorders comprising administration of novel diacylglycerol lipase inhibitors, and compositions and devices comprising said inhibitors. In some embodiments, the disorders are pancreatitis, obesity, shock or pancreatic necrosis. The invention further provides for novel ether lipid reporter compounds and methods of assaying enzymatic activity comprising contacting a compound with a novel ether lipid reporter compound.

  本发明提供了新型脂肪酶抑制剂，以及包含它们的组合物和装置。本发明还提供了治疗疾病的方法，包括给予新型二酰基甘油脂肪酶抑制剂、含有该抑制剂的组合物和装置。在某些实施例中，这些疾病包括胰腺炎、肥胖症、休克或胰腺坏死。本发明还提供了新型醚脂质报告化合物和测定酶活性的方法，其中将化合物与新型醚脂质报告化合物接触。
• Enzyme method for detecting lysophospholipids and phospholipids and for detecting and correlating conditions associated with altered levels of lysophospholipids
  申请人：Atairgin Technologies, Inc.

  公开号：US20020004213A1

  公开（公告）日：2002-01-10

  The present invention is an enzymatic method and diagnostic kits for detecting and quantifying the presence of one or more lysophospholids in a sample of bodily fluid taken from a test subject. The method uses enzymes in a two step assay and may be used to detect disease conditions associated with altered levels of lysophospholipids and to correlate such conditions with altered levels of lysophospholipids.

  本发明是一种酶法和诊断试剂盒，用于检测和量化检测对象体液样本中一种或多种溶血磷脂的存在。该方法在两步检测法中使用酶，可用于检测与溶血磷脂水平改变有关的疾病，并将这些疾病与溶血磷脂水平的改变联系起来。
• ENZYMATIC METHODS FOR MEASURING LYSOPHOSPHOLIPIDS AND PHOSPHOLIPIDS AND CORRELATION WITH DISEASES
  申请人：Atairgin Technologies, Inc.

  公开号：EP1123411A1

  公开（公告）日：2001-08-16
• EP1123411A4
  申请人：——

  公开号：EP1123411A4

  公开（公告）日：2002-05-02
• PPAR DELTA INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
  申请人：The University of Dundee

  公开号：EP1200114A2

  公开（公告）日：2002-05-02