3,4-dihydro-4,4-dimethyl-1-[2-(3,5-ditrifluoromethyl)phenoxy]phenyl-isoquinoline hydrochloride | 393780-35-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dihydro-4,4-dimethyl-1-[2-(3,5-ditrifluoromethyl)phenoxy]phenyl-isoquinoline hydrochloride
• 英文别名: 1-[2-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-4,4-dimethyl-3H-isoquinoline;hydrochloride
• CAS: 393780-35-3
• 化学式: C₂₅H₁₉F₆NO*ClH
• 分子量: 499.883
• InChiKey: XXQZQIDBEPIZCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.07
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  21.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Anellated dihydropyridines for the treatment of chronic pain
  申请人：——

  公开号：US20020045640A1

  公开（公告）日：2002-04-18

  The invention relates to the use of anellated dihydropyridines according to the following formula I, and the salts thereof with physiologically acceptable acids, for the treatment of chronic pain, wherein A is benzo or thieno and Z, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined as in the specification: 1 The inventions also relates to novel compounds of formula I and pharmaceutical compositions thereof.

  该发明涉及使用具有以下式I的环戊二氢吡啶及其与生理上可接受的酸盐，用于治疗慢性疼痛，其中A是苯并或噻吩，Z、R1、R2、R3、R4、R5和R6的定义如规范中所述。该发明还涉及式I的新化合物及其药物组合物。
• US6476047B2
  申请人：——

  公开号：US6476047B2

  公开（公告）日：2002-11-05
• [EN] USE OF ANELLATED DIHYDROPYRIDINES FOR PREPARING AGENTS FOR THE TREATMENT OF CHRONIC PAIN<br/>[FR] UTILISATION DE DIHYDROPYRIDINES ANNELEES POUR LA PREPARATION D'AGENTS DESTINES AU TRAITEMENT DE DOULEURS CHRONIQUES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2002007714A2

  公开（公告）日：2002-01-31

  The invention relates to the use of anellated dihydropyridines and the salts thereof with physiologically acceptable acids for preparing agents for the treatment of chronic pain according to general formula (I), wherein A is benzo or thieno and Z, R?1, R2, R3, R4, R5 and R6¿ are defined as in the specification, and new compounds of Formula (I).