2-(5-(2-(2-(S)-2-amino-3-methylbutanoyloxy)ethyl)aminocarbonyl-1-methylpyrrol-3-yl)amino-6-(2,6-dichlorophenyl)-8-methoxypyrido[2,3-d]pyrimidin-7-one | 1021303-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(5-(2-(2-(S)-2-amino-3-methylbutanoyloxy)ethyl)aminocarbonyl-1-methylpyrrol-3-yl)amino-6-(2,6-dichlorophenyl)-8-methoxypyrido[2,3-d]pyrimidin-7-one
• 英文别名: 2-[[4-[[6-(2,6-dichlorophenyl)-8-methoxy-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]-1-methylpyrrole-2-carbonyl]amino]ethyl (2S)-2-amino-3-methylbutanoate
• CAS: 1021303-82-1
• 化学式: C₂₇H₂₉Cl₂N₇O₅
• 分子量: 602.477
• InChiKey: GFDDKZBIQQFGGG-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  154
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• PYRIDO [2,3-D] PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS
  申请人：Murthi Krisna

  公开号：US20110201594A1

  公开（公告）日：2011-08-18

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• Pyrido-[2,3-D] Pyrimidines and Their Use as Kinase Inhibitors
  申请人：MURTHI KRISHNA

  公开号：US20140163003A1

  公开（公告）日：2014-06-12

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• US8518958B2
  申请人：——

  公开号：US8518958B2

  公开（公告）日：2013-08-27