4-nitro-N¹-[2]pyridyl-o-phenylenediamine | 78316-34-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitro-N¹-[2]pyridyl-o-phenylenediamine
• 英文别名: 4-Nitro-N¹-[2]pyridyl-o-phenylendiamin；2-(2-amino-4-nitroanilino)pyridine；4-nitro-1-N-pyridin-2-ylbenzene-1,2-diamine
• CAS: 78316-34-4
• 化学式: C₁₁H₁₀N₄O₂
• 分子量: 230.226
• InChiKey: LLSPJUPYMIFDHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-nitro-N¹-[2]pyridyl-o-phenylenediamine 、 sodium nitrite 以50%的产率得到
  参考文献：
  名称：

  HUSSEIN F. A.; ISAAC HAYFA Y., J. IRAGI CHEM. SOC., 1979, 4, NO 1-2, 19-34

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(2,4-dinitrophenyl)pyridin-2-amine 在 丙醇 作用下， 生成 4-nitro-N¹-[2]pyridyl-o-phenylenediamine
  参考文献：
  名称：

  Runti, Annali di Chimica, 1956, vol. 46, p. 406,415

  摘要：

  DOI：

文献信息

• Metallic Compound and Organic Electroluminescence Device Comprising the Same
  申请人：Suh Dong-Hack

  公开号：US20080275239A1

  公开（公告）日：2008-11-06

  The present invention relates to a light emitting transition metal compound represented by the Chemical Formula 1 and Chemical Formula 2 and an organic electroluminescence device including the same. In the above Chemical Formulae 1 and 2, M is Ir, Pt, Rh, Re, Os, or the like, m is 2 or 3 and n is 0 or 1, where the sum of m and n is 3, provided that the sum of m and n is 2 when M is Pt, X and Z are the same or different and may be N or P, and Y is O, S, or Se.

  本发明涉及一种由化学式1和化学式2表示的发光过渡金属化合物，以及包括该化合物的有机电致发光器件。在上述化学式1和2中，M为Ir、Pt、Rh、Re、Os或类似物，m为2或3，n为0或1，其中m和n的和为3，但当M为Pt时，m和n的和为2，X和Z相同或不同，可以是N或P，Y为O、S或Se。
• Benzimidazole cyclooxygenase-2 inhibitors
  申请人：Pfizer Inc.

  公开号：US06310079B1

  公开（公告）日：2001-10-30

  This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof, wherein Ar is heteroaryl; X1 and X2 are independently selected from halo, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, amino, C1-C4 alkanoyl, carboxy, carbamoyl, cyano, nitro, mercapto, (C1-C4 alkyl)thio, (C1-C4 alkyl)sulfinyl, (C1-C4 alkyl)sulfonyl, aminosulfonyl, or the like; R1 is selected from hydrogen, straight or branched C1-C4 alkyl, C3-C8 cycloalkyl, C4-C8 cycloalkenyl, phenyl , heteroaryl and the like; R2 and R3 are independently selected from hydrogen, halo, C1-C4 alkyl, phenyl and the like; or R1 and R2 can form, together with the carbon atom to which they are attached, a C5-C7 cycloalkyl ring; and m and n are independently 0, 1, 2 or 3. These compounds and pharmaceutical compositions containing such compounds are useful as analgesics and anti-inflammatory agents.

  该发明提供了以下结构的化合物：或其药学上可接受的盐，其中Ar是杂芳基；X1和X2分别选择自卤素、C1-C4烷基、羟基、C1-C4烷氧基、氨基、C1-C4烷酰基、羧基、氨基甲酰基、氰基、硝基、巯基、(C1-C4烷基)硫基、(C1-C4烷基)亚砜基、(C1-C4烷基)砜基、氨基砜基等；R1选择自氢、直链或支链C1-C4烷基、C3-C8环烷基、C4-C8环烯基、苯基、杂芳基等；R2和R3分别选择自氢、卤素、C1-C4烷基、苯基等；或R1和R2可以与它们连接的碳原子一起形成C5-C7环烷基环；m和n分别独立为0、1、2或3。这些化合物和含有这些化合物的药物组合物可用作止痛剂和抗炎药。
• Benzimidazole cyclooxygenase-2 inhibitor
  申请人：Pfizer Inc

  公开号：US20040181062A1

  公开（公告）日：2004-09-16

  This invention provides a compound of the following formula: 1 or the pharmaceutically acceptable salts thereof, wherein Ar is heteroaryl; X 1 and X 2 are independently selected from halo, C 1 -C 4 alkyl, hydroxy, C 1 -C 4 alkoxy, amino, C 1 -C 4 alkanoyl, carboxy, carbamoyl, cyano, nitro, mercapto, (C 1 -C 4 alkyl)thio, (C 1 -C 4 alkyl)sulfinyl, (C 1 -C 4 alkyl)sulfonyl, aminosulfonyl, or the like; R 1 is selected from hydrogen, straight or branched C 1 -C 4 alkyl, C 3 -C 8 cycloalkyl, C 4 -C 8 cycloalkenyl, phenyl, heteroaryl and the like; R 2 and R 3 are independently selected from hydrogen, halo, C 1 -C 4 alkyl, phenyl and the like; or R 1 and R 2 can form, together with the carbon atom to which they are attached, a C 5 -C 7 cycloalkyl ring; and m and n are independently 0, 1, 2 or 3. These compounds and pharmaceutical compositions containing such compounds are useful as analgesics and anti-inflammatory agents.

  这项发明提供了以下公式的化合物：1或其药学上可接受的盐，其中Ar是杂环芳基；X1和X2独立选择自卤素，C1-C4烷基，羟基，C1-C4烷氧基，氨基，C1-C4酰基，羧基，氨基甲酰基，氰基，硝基，巯基，（C1-C4烷基）硫醇基，（C1-C4烷基）亚砜基，（C1-C4烷基）磺酰基，氨基磺酰基等；R1选择自氢，直链或支链C1-C4烷基，C3-C8环烷基，C4-C8环烯基，苯基，杂环芳基等；R2和R3独立选择自氢，卤素，C1-C4烷基，苯基等；或者R1和R2可以与它们所附着的碳原子一起形成C5-C7环烷基环；m和n独立选择自0、1、2或3。这些化合物和含有这些化合物的药物组合物可用作镇痛剂和抗炎剂。
• Benzimidazole derivatives as cyclooxygenase-2 inhibitors
  申请人：PFIZER INC.

  公开号：EP0937722A1

  公开（公告）日：1999-08-25

  This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof, wherein    Ar is heteroaryl; X1 and X2 are independently selected from halo, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, amino, C1-C4 alkanoyl, carboxy, carbamoyl, cyano, nitro, mercapto, (C1-C4 alkyl)thio, (C1-C4 alkyl)sulfinyl, (C1-C4 alkyl)sulfonyl, aminosulfonyl, or the like; R1 is selected from hydrogen, straight or branched C1-C4 alkyl, C3-C8 cycloalkyl, C4-C8 cycloalkenyl, phenyl, heteroaryl and the like; R2 and R3 are independently selected from hydrogen, halo, C1-C4 alkyl, phenyl and the like; or R1 and R2 can form, together with the carbon atom to which they are attached, a C5-C7 cycloalkyl ring; and m and n are independently 0, 1, 2 or 3. These compounds and pharmaceutical compositions containing such compounds are useful as analgesics and anti-inflammatory agents.

  本发明提供了一种下式化合物： 或其药学上可接受的盐，其中 Ar 是杂芳基；X1 和 X2 独立选自卤、C1-C4 烷基、羟基、C1-C4 烷氧基、氨基、C1-C4 烷酰基、羧基、氨基甲酰基、氰基、硝基、巯基、(C1-C4 烷基)硫基、(C1-C4 烷基)亚磺酰基、(C1-C4 烷基)磺酰基、氨基磺酰基或类似物；R1 选自氢、直链或支链 C1-C4 烷基、C3-C8 环烷基、C4-C8 环烯基、苯基、杂芳基等；R2 和 R3 独立地选自氢、卤代、C1-C4 烷基、苯基等；或 R1 和 R2 可与所连接的碳原子一起形成 C5-C7 环烷基环；以及 m 和 n 独立地为 0、1、2 或 3。 这些化合物和含有此类化合物的药物组合物可用作镇痛剂和消炎剂。
• US6310079B1
  申请人：——

  公开号：US6310079B1

  公开（公告）日：2001-10-30