benzyl {6-[bis(2-thienylmethyl)amino]-6-oxohexyl}carbamate | 1378534-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl {6-[bis(2-thienylmethyl)amino]-6-oxohexyl}carbamate
• 英文别名: benzyl N-[6-[bis(thiophen-2-ylmethyl)amino]-6-oxohexyl]carbamate
• CAS: 1378534-30-5
• 化学式: C₂₄H₂₈N₂O₃S₂
• 分子量: 456.63
• InChiKey: QYDXAJHJMSXWDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• METHODS FOR ADMINISTERING COMPOSITIONS INCLUDING INTEGRIN AGONISTS HAVING ANTI-TUMOR ACTIVITY
  申请人：7 HILLS PHARMA LLC

  公开号：US20210145796A1

  公开（公告）日：2021-05-20

  Compositions and methods of enhancing the potency and efficacy of adoptive cell therapy using integrin-ligand stabilizers, wherein the integrin is selected from the group consisting of α4β1, α5β1, α4β7, αvβ3 and αLβ2, and contacting the effector cells ex vivo with agonists or stabilizers having the general Formula (I); methods of treating integrin-expressing cells with such stabilizers to enhance tumor infiltration; and therapeutic methods comprising administering stabilizer or agonist-treated cells to a mammal requiring treatment of solid tumors, hematologic cancers.