2-(2-amino-ethoxymethyl)-5-oxo-4-pyridin-3-yl-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester | 848586-77-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2-amino-ethoxymethyl)-5-oxo-4-pyridin-3-yl-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester
• 英文别名: ethyl 2-(2-aminoethoxymethyl)-5-oxo-4-pyridin-3-yl-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
• CAS: 848586-77-6
• 化学式: C₂₀H₂₅N₃O₄
• 分子量: 371.436
• InChiKey: ABRSELNWFRQZDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Dihydropyridine compounds for treating or preventing metabolic disorders
  申请人：Ono Mitsunori

  公开号：US20050203119A1

  公开（公告）日：2005-09-15

  This invention relates to dihydropyridine compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein A 2 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 , R 22 , and m are defined herein, and compositions comprising such compounds. The invention also relates to methods of preventing or treating metabolic disorders, such as diabetes mellitus, and conditions and complications associated with diabetes mellitus, comprising administering to a subject in need thereof a compound of formula (1) or a composition comprising such a compound. The invention further relates to kits comprising a compound of formula (I).

  本发明涉及式（I）的二氢吡啶化合物或其药学上可接受的盐、溶剂化合物、笼合物或前药，其中A2、R12、R13、R14、R15、R16、R17、R18、R19、R20、R21、R22和m如本文所定义，并且包括含有这种化合物的组合物。本发明还涉及预防或治疗代谢性疾病，如糖尿病以及与糖尿病相关的疾病和并发症的方法，包括向需要的受试者给予式（I）的化合物或包含这种化合物的组合物。本发明还涉及包含式（I）的化合物的试剂盒。
• DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS
  申请人：Synta Pharmaceuticals Corporation

  公开号：EP1663227A2

  公开（公告）日：2006-06-07
• [EN] DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS<br/>[FR] COMPOSES DE DIHYDROPYRIDINE PERMETTANT DE TRAITER OU DE PREVENIR DES TROUBLES METABOLIQUES
  申请人：SYNTA PHAMACEUTICALS CORP

  公开号：WO2005025507A2

  公开（公告）日：2005-03-24

  This invention relates to dihydropyridine compounds of formula: (I) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein A2, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, and m are defined herein, and compositions comprising such compounds. The invention also relates to methods of preventing or treating metabolic disorders, such as diabetes mellitus, and conditions and complications associated with diabetes mellitus, comprising administering to a subject in need thereof a compound of formula (I) or a composition comprising such a compound. The invention further relates to kits comprising a compound of formula (I).
• [EN] 5,6,7,8-TETRAHYDROQUINOLINES AND RELATED COMPOUNDS AND USES THEREOF<br/>[FR] 5,6,7,8-TETRAHYDROQUINOLEINES ET COMPOSES ASSOCIES ET LEURS UTILISATIONS
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2006065842A2

  公开（公告）日：2006-06-22

  [EN] This invention relates to substituted 5,6,7,8-tetrahydroquinoline compounds, substituted dihydropyridine compounds, and substituted tricyclic compounds. The invention also relates to methods of preventing or treating metabolic disorders, such as diabetes mellitus, and conditions and complications associated with diabetes mellitus, comprising administering to a subject in need thereof a compound of the invention or a composition comprising such a compound. The invention further relates to methods of treating inflammatory bowel disease, comprising administering to a subject in need thereof a compound of the invention or a composition comprising such a compound.
  [FR] Cette invention concerne des composés 5,6,7,8-tétrahydroquinoléines substitués, des composés dihydropyridines substitués et des composés tricycliques substitués. Cette invention concerne également des méthodes permettant de prévenir ou de traiter des troubles métaboliques, tels que le diabète sucré, ainsi que des états et des complications associés au diabète sucré, lesquelles méthodes consistent à administrer à un sujet nécessitant un tel traitement un composé de cette invention ou une composition contenant un tel composé. Cette invention concerne en outre des méthodes de traitement d'une maladie intestinale inflammatoire consistant à administrer à un sujet nécessitant un tel traitement un composé de cette invention ou une composition contenant un tel composé.