2-(Furan-3-ylmethylidene)-3,4-dihydronaphthalen-1-one | 1334432-56-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-(Furan-3-ylmethylidene)-3,4-dihydronaphthalen-1-one
• CAS: 1334432-56-2
• 化学式: C₁₅H₁₂O₂
• 分子量: 224.259
• InChiKey: MVZBDTRMBHPLFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(Furan-3-ylmethylidene)-3,4-dihydronaphthalen-1-one 、 1-(2-furan-2-yl-2-oxo-ethyl)-pyridinium iodide 在 ammonium acetate 、 溶剂黄146 作用下， 反应 16.0h， 生成
  参考文献：
  名称：

  Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure-activity Relationship Study of Rigid Analogues of 2,4,6-Trisubstituted Pyridine Containing 5,6-Dihydrobenzo[h]quinoline Moiety

  摘要：

  DOI：

  10.5012/bkcs.2011.32.1.303
• 作为产物：
  描述：

  3-糠醛 、 3,4-二氢-1(2H)-萘酮 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 生成 2-(Furan-3-ylmethylidene)-3,4-dihydronaphthalen-1-one
  参考文献：
  名称：

  Synthesis, characterization and spectroscopic behavior of novel 2-oxo-1,4-disubstituted-1,2,5,6-tetrahydrobenzo[h]quinoline-3-carbonitrile dyes

  摘要：

  Two synthetic pathways were adopted to synthesize the target 2-oxo-1,4-disubstituted-1,2,5,6-tetrahydro-benzo[h]quinoline-3-carbonitriles. Structure of the synthesized compounds has been characterized based on FT-IR, H-1 NMR, C-13 NMR and elemental analyses. UV-Vis and fluorescence spectroscopy measurements provided that all compounds are good absorbent and fluorescent. Fluorescence polarity study demonstrated that these compounds were sensitive to the polarity of the microenvironment provided by different solvents. In addition, spectroscopic and physicochemical parameters, including singlet absorption, extinction coefficient, Stokes shift, oscillator strength and dipole moment were investigated in order to explore the analytical potential of synthesized compounds. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.05.013

文献信息

• Enantioselective phospha-Michael reaction of diethyl phosphonate with exocyclic α,β-unsaturated benzocyclic ketones catalyzed by a dinuclear zinc−AzePhenol catalyst
  作者：Na Shao、Yong-Yang Luo、Hui-Jie Lu、Yuan-Zhao Hua、Min-Can Wang

  DOI：10.1016/j.tet.2018.03.016

  日期：2018.4

  The dinuclear zinc complexes as high performance catalysts were used to catalyze phospha-Michael reaction of exocyclic α,β-unsaturated benzocyclic ketones under mild conditions, and the desired products possessing 1-indanones or 1-tetralones skeleton were obtained with excellent enantioselectivities of up to 99%/99% ee and yields of up to 99%. The absolute stereochemistry of the major products catalyzed

  用双核锌配合物作为高性能催化剂，在温和条件下催化环外α，β-不饱和苯并环酮的磷-迈克尔反应，得到所需的具有1-茚满酮或1-四酮骨架的产物，其对映体选择性最高可达ee为99％/ 99％，产率高达99％。通过催化主要产物的绝对立体化学（R，R） - L1被确定为在（R，R），通过X射线结晶学分析-构型的3d。观察到正非线性效应，并提出了可能的机理。