N-[[6-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-3-yl]methyl]-4-(methylthioformylamino)thiobenzamide | 558465-03-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[[6-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-3-yl]methyl]-4-(methylthioformylamino)thiobenzamide
• 英文别名: N-[[6-[(4-chlorophenyl)sulfonyl-(2,5-difluorophenyl)methyl]pyridin-3-yl]methyl]-4-[methanethioyl(methyl)amino]benzenecarbothioamide
• CAS: 558465-03-5
• 化学式: C₂₈H₂₂ClF₂N₃O₂S₃
• 分子量: 602.149
• InChiKey: LCBDBPCNSYLZFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-[[6-[(4-chlorophenylsulfonyl) (2,5-difluorophenyl)methyl]pyridin-3-yl]methyl]-4-(formylmethylamino)benzamide 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以83%的产率得到N-[[6-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-3-yl]methyl]-4-(methylthioformylamino)thiobenzamide
  参考文献：
  名称：

  EP1466898

  摘要：

  公开号：

文献信息

• Beta-amyloid protein production. secretion inhibitor
  申请人：Yasukouchi Takanori

  公开号：US20050234109A1

  公开（公告）日：2005-10-20

  Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.

  提供了一种新型化合物，具有抑制β-淀粉样蛋白产生或分泌的活性。它们包括由以下公式（1）表示的化合物：并且能够被各种取代基所替换；以及它们的盐和任何一个溶剂化物。
• Morpholine derivatives
  申请人：Kubota Hideki

  公开号：US20060241302A1

  公开（公告）日：2006-10-26

  Provided is a compound capable of inhibiting production or secretion of β amyloid protein. A compound represented by the following formula (1): (wherein, R 1 represents a heterocyclic group which may have a substituent, R 2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R 3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R 4 represents a hydrogen atom or a C 1-6 alkyl group, and X represents —S—, —SO— or —SO 2 —); an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.

  提供了一种能够抑制β淀粉样蛋白产生或分泌的化合物。该化合物由以下公式（1）表示：（其中，R1代表可能具有取代基的杂环基团，R2代表可能具有取代基或杂环基团的环烃基团，R3代表可能具有取代基或杂环基团的环烃基团，R4代表氢原子或C1-6烷基基团，X代表—S—、—SO—或—SO2—）；其N-氧化物或S-氧化物；其盐；或其溶剂化物；以及含有任何一种的药物。
• BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS
  申请人：YASUKOUCHI Takanori

  公开号：US20070293495A1

  公开（公告）日：2007-12-20

  Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.

  提供了一些新化合物，具有抑制β-淀粉样蛋白的产生或分泌活性。它们包括以下式子（1）所代表的化合物：并且可以被各种取代基所替换；以及它们的盐和任何一个的溶剂化物。
• HETEROCYCLIC METHYL SULFONE DERIVATIVE
  申请人：DAIICHI PHARMACEUTICAL CO., LTD.

  公开号：EP1640366A1

  公开（公告）日：2006-03-29

  Provided is a compound capable of inhibiting production or secretion of β amyloid protein. A compound represented by the following formula (1): (wherein, R1 represents a heterocyclic group which may have a substituent, R2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R4 represents a hydrogen atom or a C1-6 alkyl group, and X represents -S-,-SO- or -SO2-) an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.

  本发明提供了一种能够抑制β淀粉样蛋白产生或分泌的化合物。 由下式（1）代表的化合物： (其中，R1代表可具有取代基的杂环基团，R2代表可具有取代基的环烃基团或可具有取代基的杂环基团，R3代表可具有取代基的环烃基团或可具有取代基的杂环基团，R4代表氢原子或C1-6烷基，X代表-S-、-SO-或-SO2-)其N-氧化物或S-氧化物；其盐；或其溶液；以及含有其中任何一种的药物。
• EP1640366
  申请人：——

  公开号：——

  公开（公告）日：——