3-(2-chlorophenyl)-4-(2-fluorophenyl)-5-(2-fluoro-4-hydroxyphenyl)isoxazole | 1373499-74-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-chlorophenyl)-4-(2-fluorophenyl)-5-(2-fluoro-4-hydroxyphenyl)isoxazole
• 英文别名: 4-[3-(2-Chlorophenyl)-4-(2-fluorophenyl)-1,2-oxazol-5-yl]-3-fluorophenol
• CAS: 1373499-74-1
• 化学式: C₂₁H₁₂ClF₂NO₂
• 分子量: 383.782
• InChiKey: IJODAJVZNQUEKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] ISOXAZOLE DERIVATIVES USED AS OESTROGEN MODULATORS<br/>[FR] DÉRIVÉS D'ISOXAZOLE UTILISÉS EN TANT QUE MODULATEURS D'OESTROGÈNE
  申请人：ORGANON NV

  公开号：WO2012052395A1

  公开（公告）日：2012-04-26

  The present invention relates to a substituted isoxazole derivative according to formula (I), wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt, solvate or prodrug thereof. The present invention also relates to a pharmaceutical composition comprising said substituted isoxazole derivatives and to their use as a contraceptive or in therapy, for instance in the treatment or prevention of estrogen-receptor mediated disorders or estrogen-receptor related physiological conditions such as climacteric disorders and osteoporosis.

  本发明涉及根据式(I)定义的一种取代异噁唑衍生物，其中变量如规范中定义，或其药学上可接受的盐、溶剂合物或前药。本发明还涉及包括所述取代异噁唑衍生物的制药组合物，以及它们作为避孕药或用于治疗的用途，例如用于治疗或预防雌激素受体介导的疾病或雌激素受体相关的生理状况，如更年期障碍和骨质疏松症。
• FREQUENCY SELECTIVE PASSIVE COMPONENT NETWORKS FOR ACTIVE IMPLANTABLE MEDICAL DEVICES UTILIZING AN ENERGY DISSIPATING SURFACE
  申请人：Greatbatch Ltd.

  公开号：EP2445433A1

  公开（公告）日：2012-05-02
• [EN] FREQUENCY SELECTIVE PASSIVE COMPONENT NETWORKS FOR ACTIVE IMPLANTABLE MEDICAL DEVICES UTILIZING AN ENERGY DISSIPATING SURFACE<br/>[FR] RÉSEAUX DE COMPOSANTS PASSIFS À SÉLECTION DE FRÉQUENCES POUR DISPOSITIFS MÉDICAUX IMPLANTABLES ACTIFS UTILISANT UNE SURFACE DE DISSIPATION D'ÉNERGIE
  申请人：GREATBATCH LTD

  公开号：WO2010151366A1

  公开（公告）日：2010-12-29

  Decoupling circuits are provided which transfer energy induced from an MRI pulsed RF field to the housing for an active implantable medical device (AIMD) which serves as an energy dissipating surface. This is accomplished through broadband filtering or by resonant filtering. In a passive component network for an AIMD, a frequency selective energy diversion circuit is provided for diverting high-frequency energy away from an AIMD lead to the AIMD housing for dissipation of said high-frequency energy.