4-((2-(9H-fluorene-3-yl)-4,5-diphenyl-1H-imidazole-1-yl)methyl)benzamide | 1054543-63-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 4-((2-(9H-fluorene-3-yl)-4,5-diphenyl-1H-imidazole-1-yl)methyl)benzamide
• 英文别名: 4-[2-(9H-fluoren-3-yl)-4,5-diphenylimidazol-1-yl-methyl]benzamide；4-[[2-(9H-fluoren-3-yl)-4,5-diphenylimidazol-1-yl]methyl]benzamide
• CAS: 1054543-63-3
• 化学式: C₃₆H₂₇N₃O
• 分子量: 517.63
• InChiKey: HABJJFRLTAZNFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  60.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL IMIDAZOLE DERIVATIVE AND THERAPEUTICAL USE THEREOF
  申请人：Industry-Academic Cooperation Foundation, Yonsei University

  公开号：EP3050875B1

  公开（公告）日：2019-03-13
• IMIDAZOLE DERIVATIVES THAT INDUCE APOPTOSIS AND THEIR THERAPEUTIC USES
  申请人：Shin In-Jae

  公开号：US20100105726A1

  公开（公告）日：2010-04-29

  The present invention relates to a pharmaceutical composition comprising compound for induction of apoptosis, a method for inducing cancer cell apoptosis, a method to suppress lymphocyte activation, a method to improve intracellular trafficking of misfolded mutants and a screening method to identify additional compounds useful for inducing apoptosis, and more specifically, it relates to pharmaceutical compositions comprising imidazole derivatives as active gradients for induction of apoptosis to treat various diseases including cancers and immune-related diseases, the method of inducing apoptosis by treating cancer cells with the said pharmaceutical composition, the method of inactivating human lymphocytes by treating lymphocytes with the said pharmaceutical composition, the method of improving intracellular trafficking of misfolded mutants by treating cells containing the mutants with the said pharmaceutical composition, and the screening method for identifying additional compound useful for inducing apoptosis, wherein cells are incubated with the said pharmaceutical composition and detected.
• NOVEL IMIDAZOLE DERIVATIVES AND THERAPEUTIC USE THEREOF
  申请人：INDUSTRY-ACA-DEMIC COORPERATION FOUNDATION, YONSEI UNIVERSITY

  公开号：US20160297768A1

  公开（公告）日：2016-10-13

  The present invention relates to a novel imidazole derivative, a pharmaceutical acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. The imidazole derivative of the present invention has excellent apoptosis activity, and thus can be useful for treating various hyperproliferative diseases including cancer.
• US8163791B2
  申请人：——

  公开号：US8163791B2

  公开（公告）日：2012-04-24
• [EN] IMIDAZOLE DERIVATIVES THAT INDUCE APOPTOSIS AND THEIR THERAPEUTIC USES<br/>[FR] DÉRIVÉS IMIDAZOLES INDUISANT L'APOPTOSE ET UTILISATIONS DE CEUX-CI À DES FINS THÉRAPEUTIQUES
  申请人：IND ACADEMIC COOP

  公开号：WO2008105565A1

  公开（公告）日：2008-09-04

  [EN] The present invention relates to a pharmaceutical composition comprising compound for induction of apoptosis, a method for inducing cancer cell apoptosis, a method to suppress lymphocyte activation, a method to improve intracellular trafficking of misfolded mutants and a screening method to identify additional compounds useful for inducing apoptosis, and more specifically, it relates to pharmaceutical compositions comprising imidazole derivatives as active gradients for induction of apoptosis to treat various diseases including cancers and immune-related diseases, the method of inducing apoptosis by treating cancer cells with the said pharmaceutical composition, the method of inactivating human lymphocytes by treating lymphocytes with the said pharmaceutical composition, the method of improving intracellular trafficking of misfolded mutants by treating cells containing the mutants with the said pharmaceutical composition, and the screening method for identifying additional compound useful for inducing apoptosis, wherein cells are incubated with the said pharmaceutical composition and detected.
  [FR] Cette invention concerne une composition pharmaceutique comprenant un composé conçu pour induire l'apoptose, un procédé consistant à induire l'apoptose des cellules tumorales, un procédé consistant à supprimer l'activation des lymphocytes, un procédé consistant à améliorer la circulation intracellulaire des mutants mal repliés et un procédé de criblage permettant d'identifier des composés supplémentaires utiles pour induire l'apoptose. Plus spécifiquement, cette invention concerne des compositions pharmaceutiques comprenant des dérivés imidazoles en tant que principes actifs pour l'induction de l'apoptose afin de traiter diverses maladies parmi lesquelles les cancers et les maladies immunitaires, ainsi que le procédé qui consiste à induire l'apopse par traitement des cellules tumorales au moyen de la composition pharmaceutique, le procédé qui consiste à inactiver les lymphocytes humains par traitement des lymphocytes avec la composition pharmaceutiques, le procédé qui consiste à améliorer la circulation intracellulaire des mutants mal repliés par traitement des cellules contenant les mutants au moyen de la composition pharmaceutique, et le procédé de criblage qui permet d'identifier une composé supplémentaire utile pour l'induction de l'apoptose. Dans ces procédés, les cellules sont incubées avec la composition pharmaceutique puis elles sont détectées.