硫酸麻黄碱 | 134-72-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 硫酸麻黄碱
• 中文别名: 麻黄碱硫酸盐
• 英文名称: L-ephedrine sulfate
• 英文别名: ephedrine sulfate；(-)-ephedrine; sulfate；(-)-Ephedrin; Sulfat；bis[(R-(R*,S*))-(β-hydroxy-α-methylphenethyl)methylammonium] sulphate；(1R, 2S)-(-)-ephedrine bisulfate；hydrogen sulfate;[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-methylazanium
• CAS: 134-72-5
• 化学式: 2C₁₀H₁₅NO*H₂O₄S
• 分子量: 428.55
• InChiKey: XVPDSDYVNYOVMP-GNAZCLTHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.68
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Anal suppository
  申请人：Detrano, Salvatore J.

  公开号：EP0094232A2

  公开（公告）日：1983-11-16

  An anal suppository characterised in that it is capable of being inserted and retained in the anal canal and melting or dissolving therein while dispersing medication to the walls of the anal canal, the suppository comprising a composition which melts or dissolves in the anal canal and having a configuration which comprises an enlarged proximal tip (12) extending from one end of a cylindrically-shaped axial shaft (16) and an enlarged distal portion (22) extending from the opposite end of the axial shaft wherein a flexible communicating means (30) composed of a flexible and atraumatic composition, relatively inert to the environment of the anal canal is embedded in the central core of the suppository from the proximal tip through the axial shaft to the distal portion and anchored in the proximal and distal portions is disclosed.

  一种肛门栓剂，其特征在于它能够插入并保留在肛管中，并在其中融化或溶解，同时将药物分散到肛管壁上、该栓剂包括一种能在肛管内融化或溶解的成分，其结构包括一个从圆柱形轴（16）的一端伸出的扩大的近端（12）和一个从轴的另一端伸出的扩大的远端（22），其中有一个由柔性和无损伤成分组成的柔性沟通装置（30）、肛管环境相对惰性的柔性沟通装置（30）嵌入栓剂的中心芯，从近端穿过轴向轴到远端部分，并固定在近端和远端部分。
• A pharmaceutical composition of phenindamine having enhanced release characteristics
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0241615A1

  公开（公告）日：1987-10-21

  A pharmaceutical composition for use in the treatment of sinus, allergy, and cold symptoms comprises an effective amount of a pharmaceutically acceptable salt of phenindamine entrapped in a leachable non-toxic wax matrix, optionally in combination with at least one analgesic, decongestant, antitussive and mixtures thereof.

  一种用于治疗鼻窦炎、过敏症和感冒症状的药物组合物，由有效量的药学上可接受的酚茚达明盐组成，酚茚达明盐被包裹在可浸出的无毒蜡基质中，可选择与至少一种镇痛剂、减充血剂、止咳剂及其混合物结合使用。
• Pharmaceutical compositions for use as mast cell stabilizer
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0571670A1

  公开（公告）日：1993-12-01

  Pharmaceutical compositions for the stabilization of mast cells or antihistamine activity comprising a bicyclic aromatic flavour compound as active ingredient or in combination with an auxiliary mast cell stabilizing ingredient.

  用于稳定肥大细胞或抗组胺活性的药物组合物，包括作为活性成分的双环芳香族化合物或与稳定肥大细胞的辅助成分结合使用。
• Pharmaceutical compositions containing sodium cromoglycate and a bicyclic aromatic flavour
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0670161A1

  公开（公告）日：1995-09-06

  Pharmaceutical compositions for the stabilization of mast cells or antihistamine activity comprising a bicyclic aromatic flavour compound as active ingredient or in combination with an auxiliary mast cell stabilizing ingredient.

  用于稳定肥大细胞或抗组胺活性的药物组合物，包括作为活性成分的双环芳香族化合物或与稳定肥大细胞的辅助成分结合使用。
• An otorhinological drug delivery device
  申请人：Schering Oy

  公开号：EP1438942A1

  公开（公告）日：2004-07-21

  The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof.

  本发明涉及一种包含至少一种药用活性剂的耳鼻喉给药装置。根据本发明，该装置包括一个包含所述至少一种药物活性剂的芯体，其中所述芯体由弹性体组合物制成，该弹性体组合物选自聚（二甲基硅氧烷）、硅氧烷基弹性体（包含连接到硅氧烷单元S原子上的3,3,3-三氟丙基）、硅氧烷基弹性体（包含聚（环氧烷）基团）及其混合物组成的组。