2-[(E)-2-(5-furan-2-yl-1-methyl-1H-[1,2,4]triazol-3-yl)-vinyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | 1312301-46-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡嗪类
• 英文名称: 2-[(E)-2-(5-furan-2-yl-1-methyl-1H-[1,2,4]triazol-3-yl)-vinyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
• 英文别名: 2-[(E)-2-[5-(furan-2-yl)-1-methyl-1,2,4-triazol-3-yl]ethenyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
• CAS: 1312301-46-4
• 化学式: C₁₆H₁₅N₇O
• 分子量: 321.341
• InChiKey: RRDVJEMNMRRERQ-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  86.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Heteroaromatic aryl triazole derivatives as PDE10A enzyme inhibitors
  申请人：Püschl Ask

  公开号：US20120309764A1

  公开（公告）日：2012-12-06

  This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

  本发明涉及一种PDE10A酶抑制剂化合物。本发明提供一种药物组合物，包括本发明化合物的治疗有效量和药学上可接受的载体。本发明还提供了制备式I化合物的方法。本发明还提供了一种治疗神经退行性疾病的方法，包括向患者施用式I化合物的治疗有效量。本发明还提供了一种治疗药物成瘾的方法，包括向患者施用式I化合物的治疗有效量。本发明还提供了一种治疗精神障碍的方法，包括向患者施用式I化合物的治疗有效量。
• HETEROAROMATIC ARYL TRIAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS
  申请人：H. Lundbeck A/S

  公开号：EP2513106B1

  公开（公告）日：2013-11-06
• US8501795B2
  申请人：——

  公开号：US8501795B2

  公开（公告）日：2013-08-06
• US8785653B2
  申请人：——

  公开号：US8785653B2

  公开（公告）日：2014-07-22