N,N'-Bis-[5-[2-(N-isopropyl-carbamimidoyl)-ethylcarbamoyl]-1-(3-methyl-butyl)-1H-pyrrol-3-yl]-terephthalamide | 386251-91-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-Bis-[5-[2-(N-isopropyl-carbamimidoyl)-ethylcarbamoyl]-1-(3-methyl-butyl)-1H-pyrrol-3-yl]-terephthalamide
• 英文别名: 1-N,4-N-bis[5-[(3-amino-3-propan-2-yliminopropyl)carbamoyl]-1-(3-methylbutyl)pyrrol-3-yl]benzene-1,4-dicarboxamide
• CAS: 386251-91-8
• 化学式: C₄₀H₆₀N₁₀O₄
• 分子量: 744.981
• InChiKey: WIRYUFLHMDEJOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  54
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  203
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• Novel aromatic compounds and poly(oxyalkylene) containing aromatic compounds possessing antibacterial, antifungal or antitumor activity
  申请人：——

  公开号：US20030212113A1

  公开（公告）日：2003-11-13

  The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): 1 Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.

  本发明提供了具有以下活性之一或多个的新型化合物：抗菌、抗真菌和抗肿瘤活性。这些化合物的化学式为（I）：1。还提供了含有这些化合物的制药组合物，制备这些化合物的方法以及使用这些化合物的方法。
• Novel compounds possessing antibacterial, antifungal or antitumor activity
  申请人：——

  公开号：US20020037856A1

  公开（公告）日：2002-03-28

  The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): 1 Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.

  本发明提供了具有以下活性之一或多个的新化合物：抗菌、抗真菌和抗肿瘤活性。这些化合物的化学式为（I）：1。同时还提供了含有这些化合物的药物组合物、制备这些化合物的方法以及使用这些化合物的方法。
• Oxazolidinone derivatives as potential antimicrobials
  申请人：——

  公开号：US20030119817A1

  公开（公告）日：2003-06-26

  The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

  本发明涉及某些取代苯基噁唑烷酮以及其合成过程。本发明还涉及含有本发明化合物作为抗微生物药物的药物组合物。这些化合物是有用的抗微生物剂，对许多人类和兽医病原体具有有效作用，包括革兰氏阳性厌氧细菌，如多重耐药葡萄球菌，链球菌和肠球菌，以及厌氧微生物，如拟杆菌属和梭菌属物种，以及耐酸微生物，如结核分枝杆菌，分枝杆菌和分枝杆菌属。
• Oxazolidinone derivatives as antimicrobials disease
  申请人：——

  公开号：US20020103186A1

  公开（公告）日：2002-08-01

  The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effec number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

  本发明涉及某些取代苯基噁唑烷酮及其合成过程。本发明还涉及含有本发明化合物作为抗微生物药物的制药组合物。这些化合物是有用的抗微生物剂，可有效对抗多种人类和兽医病原体，包括革兰氏阳性厌氧菌如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧菌如Bacterioides spp.和Clostridia spp.种，和酸性快速生长菌如结核分枝杆菌、非结核分枝杆菌和分枝杆菌属。
• [EN] OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS<br/>[FR] DERIVES D'OXAZOLIDINONE UTILISES EN TANT QU'ANTIMICROBIENS
  申请人：RANBAXY LAB LTD

  公开号：WO2002006278A1

  公开（公告）日：2002-01-24

  The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharma-ceutical compositions containing the compounds of the present invention as anti-microbials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

  本发明涉及某些取代苯基噁唑烷酮及其合成方法。本发明还涉及以本发明化合物作为抗微生物药物的药物组合物。这些化合物是有用的抗微生物剂，对多种人类和兽医病原体有效，包括革兰氏阳性需氧菌，如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧菌，如拟杆菌属和梭菌属物种，以及酸性快速生长菌，如结核分枝杆菌、鸟型分枝杆菌和分枝杆菌属物种。