3-Isopropyl-Δ⁴-piperidin | 7543-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Isopropyl-Δ⁴-piperidin
• 英文别名: 3-isopropyl-1,2,3,6-tetrahydro-pyridine；Pyridine, 1,2,5,6-tetrahydro-5-isopropyl-；3-propan-2-yl-1,2,3,6-tetrahydropyridine
• CAS: 7543-10-4
• 化学式: C₈H₁₅N
• mdl: MFCD19221923
• 分子量: 125.214
• InChiKey: YKXISWOOIBNMKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• PHENYLSULFONYLUREA DERIVATIVES USEFUL AS NLRP3 INHIBITORS
  申请人：Inflazome Limited

  公开号：US20210332020A1

  公开（公告）日：2021-10-28

  The present invention relates to phenylsulfonylureas and phenylsulfonylthioureas, wherein the phenyl ring is substituted with a monovalent group comprising either (i) an aryl or a heteroaryl group, or (ii) a nitrogen-containing heterocyclic group, and wherein the group attached to the terminal nitrogen atom of the urea group is a 6-membered cyclic group substituted at the 2- and 4-positions. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP 3 inhibition.
• US9120774B2
  申请人：——

  公开号：US9120774B2

  公开（公告）日：2015-09-01
• [EN] NOVOBIOCIN ANALOGUES HAVING MODIFIED SUGAR MOIETIES<br/>[FR] ANALOGUES DE NOVOBIOCINE COMPORTANT DES GROUPES FONCTIONNELS GLUCIDIQUES MODIFIÉS
  申请人：UNIV KANSAS

  公开号：WO2010096650A1

  公开（公告）日：2010-08-26

  The disclosure provides novobiocin analogues with noviose replacements which are useful as Hsp90 inhibitors in the treatment of cancer.