4-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-N-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)sulfonyl]benzamide | 1235965-40-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-N-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)sulfonyl]benzamide
• 英文别名: 4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)sulfonyl]benzamide
• CAS: 1235965-40-8
• 化学式: C₃₈H₄₂ClN₃O₃S
• 分子量: 656.289
• InChiKey: XHQMEZQMJATMTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  46
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  78.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
  申请人：Hexamer Laura A.

  公开号：US20100184750A1

  公开（公告）日：2010-07-22

  Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

  揭示了一种抑制抗凋亡Bcl-2蛋白活性的化合物，含有这些化合物的组合物以及治疗在其中表达抗凋亡Bcl-2蛋白的疾病的方法。
• Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
  申请人：AbbVie Inc.

  公开号：EP2511264B1

  公开（公告）日：2015-03-11
• US8426422B2
  申请人：——

  公开号：US8426422B2

  公开（公告）日：2013-04-23
• [EN] APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES<br/>[FR] AGENTS INDUISANT L'APOPTOSE DESTINÉS AU TRAITEMENT DU CANCER ET DE MALADIES IMMUNES ET AUTO-IMMUNES
  申请人：ABBOTT LAB

  公开号：WO2010083441A2

  公开（公告）日：2010-07-22

  Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.