4-(α-Methyl-α-ethyl-propyl)-pyridin | 104178-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(α-Methyl-α-ethyl-propyl)-pyridin
• 英文别名: 4-(1-ethyl-1-methyl-propyl)-pyridine；4-(3-Methylpentan-3-yl)pyridine
• CAS: 104178-05-4
• 化学式: C₁₁H₁₇N
• 分子量: 163.263
• InChiKey: OSVHSPVXVCKSCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• POSITIVE RESIST COMPOSITION AND PATTERN FORMING PROCESS
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US20210247694A1

  公开（公告）日：2021-08-12

  A positive resist composition comprising a base polymer comprising recurring units having a carboxyl group whose hydrogen is substituted by a pyridine ring-containing tertiary hydrocarbyl group.

  一种正性光刻胶组合物，包括基础聚合物，该聚合物包含具有羧基的重复单元，其氢被含有吡啶环的三级烃基取代。
• Use of Cyclooxygenase-2 Inhibitors for the Treatment of Depressive Disorders
  申请人：Hagan James

  公开号：US20070270428A1

  公开（公告）日：2007-11-22

  The invention concerns the use of compounds of formula (I), (II) and (III): which are COX-2 (cyclooxygenase-2) inhibitors, and pharmaceutically acceptable salts or solvates thereof, for the treatment of depressive disorders in combination with an effective amount of a second component which is a selective serotonin reuptake inhibitor.

  本发明涉及使用式（I），（II）和（III）的化合物：这些化合物是COX-2（环氧合酶-2）抑制剂，以及其药学上可接受的盐或溶剂，与第二成分的有效量结合使用，该第二成分是选择性血清素再摄取抑制剂，用于治疗抑郁症。
• AFFINITY LIGANDS AND METHODS FOR PROTEIN PURIFICATION
  申请人：Hearn Milton TW

  公开号：US20120259094A1

  公开（公告）日：2012-10-11

  The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilise the adsorbents in the purification of proteins by affinity chromatography. The affinity ligand-matrix conjugates of the present invention comprise ligands of general formula (I): wherein m represents an integer from 0-2, n represents an integer from 0-6, p represents an integer from 0-4, R 1 represents H or C 1-3 alkyl, R 2 is an optional substituent, and X is the position at which the ligand is immobilized, optionally via a linker.

  本发明涉及亲和配体和化学亲和配体-基质共轭物，用作色谱吸附剂以及利用该吸附剂在亲和色谱中纯化蛋白质的方法。本发明的亲和配体-基质共轭物包括一般式（I）的配体： 其中m表示0-2的整数，n表示0-6的整数，p表示0-4的整数，R1表示H或C1-3烷基，R2是可选的取代基，X是配体通过链接剂固定的位置。
• MAP kinase modulators and uses thereof
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US11149020B2

  公开（公告）日：2021-10-19

  The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.

  本发明提供了新型 MAP 激酶抑制剂和包含这些抑制剂的组合物。在某些实施方案中，MAP 激酶抑制剂是 p38α MAP 激酶抑制剂。本发明进一步提供了治疗疾病的方法，包括施用 MAP 激酶抑制剂或包含 MAP 激酶抑制剂的组合物。在某些实施方案中，疾病是阿尔茨海默病、渐冻人症、亨廷顿氏病或帕金森氏病。
• P2X7 MODULATORS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US20170342066A1

  公开（公告）日：2017-11-30

  The present invention is directed to compounds of Formula (I), which includes enantiomer and diasteromers thereof: The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.