2-(phenoxycarbonyloxy)ethyl methacrylate | 261352-69-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(phenoxycarbonyloxy)ethyl methacrylate
• 英文别名: 2-Phenoxycarbonyloxyethyl 2-methylprop-2-enoate
• CAS: 261352-69-6
• 化学式: C₁₃H₁₄O₅
• 分子量: 250.251
• InChiKey: RMHKEIKKTVRVCO-UHFFFAOYSA-N

物化性质

• 沸点：
  363.7±34.0 °C(Predicted)
• 密度：
  1.167±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲基丙烯酸羟乙酯 、 氯甲酸苯酯 以 二氯甲烷 为溶剂， 反应 70.0h， 以90%的产率得到2-(phenoxycarbonyloxy)ethyl methacrylate
  参考文献：
  名称：

  Functional and reactive polymethacrylates suitable for preparation of peptide/protein–polymer conjugates

  摘要：

  Three reactive polymers, poly(para-nitrophenoxycarbonyloxyethyl methacrylate-co-methyl methacrylate) P(p-NPCEMA-co-MMA) [rCoP1], poly(methyl methacrylate-co-butyl methacrylate-co-allyl methacrylate-co-phenoxycarbonyloxyethyl methacrylate) P(MMA-co-BMA-co-AMA-co-PCEMA) [rCoP2) and poly(methyl methacrylate-co-dimethylaminopropyl methacrylate-co-dodecyl methacrylate-co-phenoxycarbonyloxyethyl methacrylate) P(MMA-co-DMAPMA-co-DMA-co-PCEMA) [rCoP3], respectively, were prepared following two synthetic concepts. Following the first concept, p-NPCEMA and PCEMA were prepared starting with commercially available HEMA and were copolymerized via ATRP with MMA, BMA and AMA. According to the second concept phenoxycarbonyloxy decorated polymethacrylates were obtained via polymer analogous reaction of a HEMA containing functional polymethacrylate, P(MMA-co-DMAPMA-co-DMA-co-HEMA) [fCoP], obtained via a cascade reaction of enzymatic transacylation and free radical polymerization. The highly reactive poly(methacrylate)s and silk peptides, hen egg-white lysozyme and Candida antarctica lipase B were used for the preparation of protein/peptide-poly(methacrylate) bioconjugates. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.reactfunctpolym.2010.07.016

文献信息

• REAKTIVE CYCLISCHE CARBONATE UND HARNSTOFFE ZUR MODIFIZIERUNG VON BIOMOLEKÜLEN, POLYMEREN UND OBERFLÄCHEN
  申请人：Henkel AG & Co. KGaA

  公开号：EP1692126B1

  公开（公告）日：2012-11-07
• Reactive cyclic carbonates and ureas used for modifying biomolecules, polymers, and surfaces
  申请人：Keul Helmut

  公开号：US20070092656A1

  公开（公告）日：2007-04-26

  Disclosed are reactive cyclic carbonates and ureas of formula (I) or (II), wherein R and X have the meaning indicated in the description. Said carbonates and ureas allow functional groups to be specifically introduced into biomolecules, polymers, and surfaces in mild conditions.
• US5488089A
  申请人：——

  公开号：US5488089A

  公开（公告）日：1996-01-30
• US7728069B2
  申请人：——

  公开号：US7728069B2

  公开（公告）日：2010-06-01