4-((3-(3-amino-1-hydroxypropyl)phenylthio)methyl)heptan-4-ol | 1215076-23-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-((3-(3-amino-1-hydroxypropyl)phenylthio)methyl)heptan-4-ol
• 英文别名: 4-[[3-(3-amino-1-hydroxypropyl)phenyl]sulfanylmethyl]heptan-4-ol
• CAS: 1215076-23-5
• 化学式: C₁₇H₂₉NO₂S
• 分子量: 311.489
• InChiKey: OAVVMCJRMCJQOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  91.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  dimethyl sulfide borane 、 3-hydroxy-3-(3-(2-hydroxy-2-propylpentylthio)phenyl)propanenitrile 以gave Example 119 as a colorless semi solid的产率得到4-((3-(3-amino-1-hydroxypropyl)phenylthio)methyl)heptan-4-ol
  参考文献：
  名称：

  SULPHUR-LINKED COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS

  摘要：

  提供了硫连接化合物，其制药组合物以及使用所述化合物和组合物治疗眼科疾病和疾病的方法，例如年龄相关性黄斑变性和斯塔加德病。

  公开号：

  US20100093865A1

文献信息

• METHODS FOR THE TREATMENT OF DIABETIC RETINOPATHY AND OTHER OPHTHALMIC DISEASES
  申请人：Acucela Inc.

  公开号：EP3741742A1

  公开（公告）日：2020-11-25

  Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

  本文提供了治疗眼科疾病或病症的方法，例如与患者糖尿病相关的眼科疾病或紊乱。本文还提供了治疗早产儿视网膜病变的方法。此外，本文还提供了治疗患者湿性年龄相关性黄斑变性的方法。这些方法包括向有需要的患者施用本文公开的化合物，以抑制或减缓此类病症的一种或多种体征或症状。
• Methods for the treatment of diabetic retinopathy and other ophthalmic diseases
  申请人：Acucela Inc.

  公开号：US10730825B2

  公开（公告）日：2020-08-04

  Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

  本文提供了治疗眼科疾病或病症的方法，例如与患者糖尿病相关的眼科疾病或紊乱。本文还提供了治疗早产儿视网膜病变的方法。此外，本文还提供了治疗患者湿性年龄相关性黄斑变性的方法。这些方法包括向有需要的患者施用本文公开的化合物，以抑制或减缓此类病症的一种或多种体征或症状。
• METHODS FOR THE TREATMENT OF PROLIFERATIVE DIABETIC RETINOPATHY
  申请人：Acucela Inc.

  公开号：EP2844636B1

  公开（公告）日：2020-04-22
• Methods for the Treatment of Diabetic Retinopathy and other Ophthalmic Diseases
  申请人：Acucela Inc.

  公开号：US20210171435A1

  公开（公告）日：2021-06-10

  Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
• US9957224B2
  申请人：——

  公开号：US9957224B2

  公开（公告）日：2018-05-01