(6S,7S)-N(7)-hydroxy-N(6)-[2-(4-methoxyphenyl)ethyl]-5-methyl-5-azaspiro[2.5]octane-6,7-dicarboxamide | 791826-51-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (6S,7S)-N(7)-hydroxy-N(6)-[2-(4-methoxyphenyl)ethyl]-5-methyl-5-azaspiro[2.5]octane-6,7-dicarboxamide
• 英文别名: (6S,7S)-7-N-hydroxy-6-N-[2-(4-methoxyphenyl)ethyl]-5-methyl-5-azaspiro[2.5]octane-6,7-dicarboxamide
• CAS: 791826-51-2
• 化学式: C₁₉H₂₇N₃O₄
• 分子量: 361.441
• InChiKey: WIGVMCGAAKVZKB-HOTGVXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  90.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Aza spiro alkane derivatives as inhibitors of metalloproteases
  申请人：——

  公开号：US20040259896A1

  公开（公告）日：2004-12-23

  The present invention provides a compound of Formula I or Formula II: 1 enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.

  本发明提供了公式I或公式II的化合物：1对映异构体，对映体，前药，溶剂化物，代谢物或其药学上可接受的盐，其中组分变量在此处提供。公式I和II的化合物是金属蛋白酶调节剂，可用于治疗与金属蛋白酶活性相关的疾病，如关节炎，癌症，心血管疾病，皮肤疾病，炎症和过敏症。
• AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases
  申请人：INCYTE CORPORATION

  公开号：US20140187530A1

  公开（公告）日：2014-07-03

  The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.

  本发明提供公式I或公式II的化合物：其对映体，顺反异构体，前药，溶剂化物，代谢物或其药学上可接受的盐，其中组成变量在此提供。公式I和II的化合物是金属蛋白酶调节剂，并且在治疗与金属蛋白酶活性相关的疾病，例如关节炎，癌症，心血管疾病，皮肤疾病，炎症和过敏症方面是有用的。
• Aza spiro alkane derivatives as inhibitors of metallproteases
  申请人：Incyte Corporation

  公开号：EP2617419A1

  公开（公告）日：2013-07-24

  The present invention provides a compound of Formula (I) or Formula (II): enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula (I) and (II) are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.

  本发明提供了式(I)或式(II)化合物：其对映体、非对映体、原药、溶物、代谢物或药学上可接受的盐，其中组成变量在此提供。 式（I）和（II）化合物是金属蛋白酶的调节剂，可用于治疗与金属蛋白酶活性相关的疾病，如关节炎、癌症、心血管疾病、皮肤疾病、炎症和过敏性疾病。
• AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES
  申请人：Incyte Corporation

  公开号：EP1622569B1

  公开（公告）日：2015-12-02
• EP1622569A4
  申请人：——

  公开号：EP1622569A4

  公开（公告）日：2008-08-27