pentabenzoyl al-D-glucose | 96810-52-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: pentabenzoyl al-D-glucose
• 英文别名: pentabenzoyl-al-D-glucose；glucose pentabenzoate；Penta-O-benzoyl-aldehydo-D-glucose；penta-O-Benzoyl-D-Glucose；2,3,4,5,6-Penta-O-benzoyl-D-glucose；Glucose-pentabenzoat；[(2R,3R,4S,5R)-2,3,4,5-tetrabenzoyloxy-6-oxohexyl] benzoate
• CAS: 96810-52-5
• 化学式: C₄₁H₃₂O₁₁
• 分子量: 700.698
• InChiKey: SIPWCDUYKOLEKU-NJMTUYGZSA-N

物化性质

• 熔点：
  81-82 °C
• 沸点：
  816.1±65.0 °C(Predicted)
• 密度：
  1.302±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  52
• 可旋转键数：
  20
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  149
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  pentabenzoyl al-D-glucose 在 乙醚 、 sodium hydrogensulfite 作用下， 生成 (1Ξ)-D-gluco-2,3,4,5,6-pentakis-benzoyloxy-1-hydroxy-hexane-1-sulfonic acid ; sodium-salt
  参考文献：
  名称：

  Brigl; Muehlschlegel, Chemische Berichte, 1930, vol. 63, p. 1551,1555

  摘要：

  DOI：
• 作为产物：
  描述：

  penta-O-benzoyl-aldehydo-D-glucose-diethyldithioacetal 在 甲酸 作用下， 生成 pentabenzoyl al-D-glucose
  参考文献：
  名称：

  Brigl; Muehlschlegel, Chemische Berichte, 1930, vol. 63, p. 1551,1555

  摘要：

  DOI：

文献信息

• A new synthesis of C-nucleosides by 1,3-dipolar cycloaddition of chiral azomethine imines to methyl acrylate the stereoselective synthesis of fused pyrazoles
  作者：Marko Žličar、Branko Stanovnik、Miha Tišler

  DOI：10.1016/s0040-4020(01)80470-1

  日期：1992.1

  A new stereoselective synthesis of C-nucleosides is described. The fused NH,NH-dihydro pyrazole derivative was transformed with carbohydrates into chiral azomethine imines –. The 1,3-dipolar cycloaddition of these to methyl acrylate affords the nucleosides –. The compound was prepared from , unprotected D-ribose and methyl acrylate in a one-pot procedure. The synthesis is highly stereoselective to

  描述了C-核苷的新的立体选择性合成。稠合的NH，NH-二氢吡唑衍生物与碳水化合物一起转化为手性偶氮甲亚胺- 。它们与丙烯酸甲酯的1，3-偶极环加成可提供核苷– 。该化合物是通过一锅法由未保护的D-核糖和丙烯酸甲酯制备的。合成具有很高的立体选择性，可得到> 62; 95％ee的产物，除了。
• INOSITOL AND TREHALOSE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES COMPRISING THE SAME
  申请人：Chung Sung-Kee

  公开号：US20110224423A1

  公开（公告）日：2011-09-15

  The invented inositol and trehalose derivatives, prepared by introducing multiple units of the guanidine group to the backbone molecules, show excellent blood-brain barrier permeability, and accordingly, it can be easily transported to the brain tissues and utilized for the treatment of neurodegenerative diseases such as Alzheimer's disease and Huntington's disease.

  通过将多个胍基单元引入骨架分子，制备出的肌醇和海藻糖衍生物表现出优异的血脑屏障渗透性，因此可以轻松地运输到大脑组织并用于治疗神经退行性疾病，如阿尔茨海默病和亨廷顿病。
• CELLULOSE ACYLATE FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY USING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20160124123A1

  公开（公告）日：2016-05-05

  A cellulose acylate film, containing at least: a cellulose acylate; and a compound represented by the following Formula (I): wherein R 1 , R 3 and R 5 each independently designate a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, or an aromatic group, which groups may have a further substituent; with the proviso that at least one of R 1 , R 3 and R 5 is an alkyl group substituted with a group having a ring structure or a cycloalkyl group, and the total number of the ring structures existing in R 1 , R 3 and R 5 is 3 or more.

  一种纤维素酰基膜，至少包含以下成分：纤维素酰基；以及下式（I）所表示的化合物：其中R1、R3和R5各自独立地表示氢原子、烷基、环烷基、烯基或芳基，这些基团可能具有进一步的取代基；但至少其中之一的R1、R3和R5是取代有环结构的烷基或环烷基，且存在于R1、R3和R5中的环结构总数为3个或更多。
• TREHALOSE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES COMPRISING THE SAME
  申请人：POSTECH ACADEMY-INDUSTRY FOUNDATION

  公开号：EP2987798A1

  公开（公告）日：2016-02-24

  The invented trehalose derivatives, prepared by introducing multiple units of the guanidine group to the backbone molecules, show excellent blood-brain barrier permeability, and accordingly, it can be easily transported to the brain tissues and utilized for the treatment of neurodegenerative diseases such as Alzheimer's disease and Huntington's disease.

  通过在骨架分子中引入多个胍基单位而制备的曲哈洛糖衍生物具有极佳的血脑屏障渗透性，因此可以很容易地运输到脑组织，用于治疗阿尔茨海默病和亨廷顿病等神经退行性疾病。
• Optical film, and polarizing plate and liquid crystal display device employing same
  申请人：FUJIFILM Corporation

  公开号：US10160846B2

  公开（公告）日：2018-12-25

  The inventions are an optical film containing cellulose acylate and a compound having a structure denoted by General Formula (A) described below, and a polarizing plate and a liquid crystal display device employing the optical film. L represents n-valent connecting group, n represents an integer of greater than or equal to 2, and A represents a heterocyclic group denoted by General Formula (I). R1, R3, and R5 represent a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an aryl group, or a heteroaryl group. Here, any one of R1, R3, and R5 is bonded to L.

  本发明是一种含有酰基纤维素和具有下述通式（A）表示的结构的化合物的光学薄膜，以及采用该光学薄膜的偏光板和液晶显示装置。 L 代表正价连接基团，n 代表大于或等于 2 的整数，A 代表通式（I）表示的杂环基团。R1、R3 和 R5 代表氢原子、烷基、环烷基、烯基、芳基或杂芳基。这里，R1、R3 和 R5 中的任一个与 L 键合。