4-hydroxy-3-pentyl-2(5H)-furanone | 71413-18-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 4-hydroxy-3-pentyl-2(5H)-furanone
• 英文别名: 4-Hydroxy-3-pentyl-5H-furan-2-one；3-hydroxy-4-pentyl-2H-furan-5-one
• CAS: 71413-18-8
• 化学式: C₉H₁₄O₃
• 分子量: 170.208
• InChiKey: MSRFIWKZRFSNDN-UHFFFAOYSA-N

物化性质

• 熔点：
  112-113 °C(Solv: chloroform (67-66-3); hexane (110-54-3))
• 沸点：
  314.5±42.0 °C(Predicted)
• 密度：
  1.137±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-氯-4-[1-(4-氯苯基)乙烯基]苯 、 4-hydroxy-3-pentyl-2(5H)-furanone 在 manganese triacetate 、 溶剂黄146 作用下， 反应 11.0h， 以89%的产率得到4,4-bis(4-chlorophenyl)-1-hydroxy-6-pentyl-2,3,8-trioxabicyclo[4.3.0]nonan-7-one
  参考文献：
  名称：

  Synthesis of Peroxylactones Using Mn(III)-Catalyzed Aerobic Oxidation

  摘要：

  The aerobic oxidation of tetronic acid in the presence of 1,1-disubstituted alkenes afforded hydroperoxyethyl-peroxylactones, while a similar reaction using 3-alkyl-substituted tetronic acids gave stable crystalline peroxylactones in good to excellent yields. The oxidation using a stoichiometric amount of manganese(III) acetate did not give the bicyclic lactone but the ethenyland/or ethyl-tetronic acid derivatives.

  DOI：

  10.3987/com-11-12241
• 作为产物：
  描述：

  4-hydroxy-3-(1-oxopentyl)-2(5H)-furanone 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 以90%的产率得到4-hydroxy-3-pentyl-2(5H)-furanone
  参考文献：
  名称：

  从 3-酰基四电子酸方便地合成 3-烷基四电子酸

  摘要：

  摘要 在温和的反应条件下，3-酰基四电子酸的还原脱氧以高产率提供了 3-烷基四电子酸。

  DOI：

  10.1080/00397919208020844

文献信息

• Cyclopentanone derivatives, method of synthesis and uses thereof
  申请人：Neuropharma S.A.

  公开号：EP1939192A1

  公开（公告）日：2008-07-02

  The present invention relates to cyclopentanone derivatives of formula (I), their method of synthesis and uses thereof. Concretely, the compounds disclosed have proved to be inhibitors of glycogen synthase kinase 3β, GSK-3 β, which is known to be involved in different disease and conditions, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a GSK-3 mediated disease or condition.

  本发明涉及公式（I）的环戊酮衍生物，其合成方法及用途。具体来说，所披露的化合物已被证明是糖原合成酶激酶3β（GSK-3β）的抑制剂，GSK-3β已知参与不同疾病和病况，如阿尔茨海默病或非胰岛素依赖型糖尿病。本发明还涉及包含这些化合物的药物组合物。此外，本发明旨在将这些化合物用于制造治疗和/或预防GSK-3介导的疾病或病况的药物。
• Substituted aryloximes
  申请人：Havran Marie Lisa

  公开号：US20050070584A1

  公开（公告）日：2005-03-31

  The present invention relates to substituted aryl oximes and methods of using them.

  本发明涉及取代的芳香基氧化亚氮及其使用方法。
• 3-Aryl-4-Hydroxyfuranone compounds and the human and animal health use thereof
  申请人：Caufield Eugene Craig

  公开号：US20050054721A1

  公开（公告）日：2005-03-10

  The present invention provides a compound of formula I and the use thereof for the inhibition of bacterial cell wall biosynthesis and for the therapeutic treatment of bacterial infection or disease in a patient in need thereof. The present invention also provides the use of the formula I compound for the control of ecto- or endoparasites in homeothermic animals.

  本发明提供了一种I式化合物及其用于抑制细菌细胞壁生物合成并用于治疗患有细菌感染或疾病的患者的用途。本发明还提供了使用I式化合物用于控制恒温动物体内或体外寄生虫的方法。
• [EN] SUBSTITUTED HETEROARYL BENZOFURAN ACIDS<br/>[FR] ACIDES HETEROARYL BENZOFURANE SUBSTITUES
  申请人：WYETH CORP

  公开号：WO2005030760A1

  公开（公告）日：2005-04-07

  The present invention relates generally to substituted heteroaryl benzofuran acids and methods of using them (I); or a pharmaceutically acceptable salt or ester form therof wherein: R, R1, R2 and R3 are, independently, hydrogen, alkyl, cycloalkyl, alkanoyl, halo, hydroxy, aryl, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, or perfluoroalkoxy; R4 is hydrogen, alkyl, perfluoroalkyl, alkenyl, alkynyl, arylalkenyl, arylalkynyl, aryl,-C(=O)R5, -C(=S)R5, -CH2R5, OR -CH(OH)R5; R5 is hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, perfluoroalkyl, aryl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, alkylaryl, alkenylaryl, or alkynylaryl; R6 is hydrogen, alkyl, aryl, or arylalkyl; x1, x2, x3, x4, x5, x6, x7, and x8 are, independently, carbon or nitrogen, wherein at least one of x1-x8 is a nitrogen atom; n is an integer from 0-6; and A is COOH or an acid mimic or a pharmaceutically acceptable salt thereof.

  本发明涉及一般地替代杂环芳基苯并呋喃酸及其使用方法（I）；或其药用可接受的盐或酯形式，其中：R、R1、R2和R3独立地是氢、烷基、环烷基、烷酰基、卤素、羟基、芳基、全氟烷基、烷氧基、氨基、烷基氨基、二烷基氨基或全氟烷氧基；R4是氢、烷基、全氟烷基、烯基、炔基、芳基烯基、芳基炔基、芳基、-C（=O）R5、-C（=S）R5、-CH2R5、OR或-CH（OH）R5；R5是氢、C1-C8烷基、C3-C8环烷基、全氟烷基、芳基、烯基、炔基、芳基烷基、芳基烯基、芳基炔基、烷基芳基、烯基芳基或炔基芳基；R6是氢、烷基、芳基或芳基烷基；x1、x2、x3、x4、x5、x6、x7和x8独立地是碳或氮，其中至少一个是氮原子；n是0-6之间的整数；A是COOH或酸模拟物或其药用可接受的盐。
• Substituted naphthyl benzothiophene acids
  申请人：Elokdah Mahmoud Hassan

  公开号：US20050070587A1

  公开（公告）日：2005-03-31

  The present invention relates generally to substituted naphthyl benzothiophene acids and methods of using them

  本发明一般涉及替代萘基苯并噻吩酸及其使用方法。