5-chloro-2-isopropyl-phenol | 90416-28-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-chloro-2-isopropyl-phenol
• 英文别名: 5-Chlor-2-isopropyl-phenol；5-Chloro-2-(propan-2-YL)phenol；5-chloro-2-propan-2-ylphenol
• CAS: 90416-28-7
• 化学式: C₉H₁₁ClO
• 分子量: 170.639
• InChiKey: IULZIXOSMDNWLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Raf inhibitor compounds and methods of use thereof
  申请人：Miknis Greg

  公开号：US20070049603A1

  公开（公告）日：2007-03-01

  Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

  公式I的化合物对抑制Raf激酶和治疗由此介导的疾病有用。公开了使用公式I的化合物及其立体异构体、几何异构体、互变异构体、溶剂合物和药学上可接受的盐，在哺乳动物细胞中进行体外、体内和体内诊断、预防或治疗此类疾病或相关病理条件的方法。
• Hydrolytically-Resistant Boron-Containing Therapeutics And Methods Of Use
  申请人：Lee Ving

  公开号：US20070265226A1

  公开（公告）日：2007-11-15

  Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

  揭示了硼衍生物的组合物和使用方法，包括苯硼酚酯、苯氮硼酚酯和苯硫硼酚酯，作为治疗由真菌、酵母、细菌或病毒引起的疾病的治疗剂，以及合成所述药剂和组合物的方法。
• Compounds for inhibiting NLRP3 and uses thereof
  申请人：Ventus Therapeutics U.S., Inc.

  公开号：US11319319B1

  公开（公告）日：2022-05-03

  The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

  本公开涉及NLRP3抑制剂，用于治疗被该蛋白抑制的疾病和障碍，并具有公式（I）：
• 2,3,6-trisubstituted-4-pyrimidone derivatives
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2305651A1

  公开（公告）日：2011-04-06

  A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of: represents piperazine ring or piperidine ring.

  一种具有 tau 蛋白激酶 1 抑制活性的嘧啶酮衍生物，由式 (I) 或其盐或其溶液或其水合物表示： 其中 Q 代表 CH 或氮原子；R 代表 C1-C12 烷基；环的： 代表哌嗪环或哌啶环。
• Volatile applications against pathogens
  申请人：AGROFRESH INC.

  公开号：US10765117B2

  公开（公告）日：2020-09-08

  This invention is related to the use of a volatile antimicrobial compound against pathogens affecting humans comprising contacting infected areas with an atmosphere containing an effective amount of a volatile antimicrobial compound in gaseous form. The volatile antimicrobial compounds provided include certain oxaborole compounds, for example benzoxaboroles. Delivery systems are provided to take advantage of the volatile nature of these antimicrobial compounds. The method and use disclosed can be combined with other volatile compounds.

  本发明涉及使用挥发性抗菌化合物来对付影响人类的病原体，包括使受感染区域与含有有效量气态挥发性抗菌化合物的环境接触。所提供的挥发性抗菌化合物包括某些氧硼化合物，例如苯并氧硼化合物。提供的给药系统可利用这些抗菌化合物的挥发性。所公开的方法和用途可与其他挥发性化合物结合使用。