3-(benzylideneamino)-7-chloro-2-phenylquinazolin-4(3H)-one | 1316302-77-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(benzylideneamino)-7-chloro-2-phenylquinazolin-4(3H)-one
• CAS: 1316302-77-8
• 化学式: C₂₁H₁₄ClN₃O
• 分子量: 359.815
• InChiKey: WTVJPNKSIRHZLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.25
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  7-chloro-2-phenyl-4H-benzo[d][1,3]oxazin-4-one 在 一水合肼 、 溶剂黄146 作用下， 反应 6.5h， 生成 3-(benzylideneamino)-7-chloro-2-phenylquinazolin-4(3H)-one
  参考文献：
  名称：

  Anti-convulsant potential of quinazolinones

  摘要：

  一系列新型喹唑啉衍生物经过不同的筛选器进行虚拟筛选，并针对电刺激和化学诱导的癫痫发作评估其抗抽搐活性。

  DOI：

  10.1039/c6ra01284a

文献信息

• 7-chloro-3-(substituted benzylidene/phenyl ethylidene amino)-2-phenylquinazolin-4(3H)-ones: synthesis, antimicrobial and antitubercular evaluation
  作者：Rajarathinam Vijai Anand、Balasubramanian Narasimhan、Ramachandran Vasanthakumari Pradeep Chandran、Koralakundata Narsimha Jayaveera

  DOI：10.1007/s00044-011-9813-z

  日期：2012.10

  In this study, a series of 7-chloro-3-(substituted benzylidene/phenyl ethylidene amino)-2-phenyl quinazolin-4(3H)-ones (1-10) were prepared and evaluated for antitubercular activity against Mycobacterium tuberculosis (MTB). The antitubercular screening results indicated that 7-chloro-3-(4-(dimethylamino)benzylidene amino)-2-phenylquinazolin-4(3H)-one (10) was the most potent one (MIC = 0.78 x 10(-3) mu M) and exhibited activity equivalent to the standard compound isoniazid (MIC = 0.80 x 10(-3) mu M). Further, the synthesized compounds were tested for their antibacterial activity against Gram positive and Gram negative bacteria. The comparison of antibacterial and antimycobacterial results indicated that different structural requirements are necessary for a compound to be effective against bacterial and mycobacterial targets.