| 1554539-72-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1554539-72-8
• 化学式: C₂₂H₂₃NOSi
• 分子量: 345.516
• InChiKey: QGDCTNIVAPQKSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.26
• 重原子数：
  25.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  25.02
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  吡咯 、 在 C₇₂H₄₅NO₆P₂ 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以86%的产率得到
  参考文献：
  名称：

  Enantioselective Synthesis of Triarylmethanes by Chiral Imidodiphosphoric Acids Catalyzed Friedel–Crafts Reactions

  摘要：

  The first enantioselective synthesis of pyrrolyl-substituted triarylmethanes has been accomplished using a novel imidodiphosphoric acid catalyst, which is derived from two (R)BINOL frameworks with different 3,3'-substituents. This strategy was also expanded to the synthesis of bis(indolyl)-substituted triarylmethanes with high enantioselectivities, which could only be obtained with moderate ee values in previous reports. These two efficient Friedel-Crafts alkylation processes feature low catalyst loading, broad functional group compatibilities, and the potential to provide practical pathways for the synthesis of enantioenriched bioactive triarylmethanes.

  DOI：

  10.1021/ol403680c
• 作为产物：
  描述：

  1-萘甲醛 在 咪唑 、 四甲基胍 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 24.5h， 生成
  参考文献：
  名称：

  Enantioselective Synthesis of Triarylmethanes by Chiral Imidodiphosphoric Acids Catalyzed Friedel–Crafts Reactions

  摘要：

  The first enantioselective synthesis of pyrrolyl-substituted triarylmethanes has been accomplished using a novel imidodiphosphoric acid catalyst, which is derived from two (R)BINOL frameworks with different 3,3'-substituents. This strategy was also expanded to the synthesis of bis(indolyl)-substituted triarylmethanes with high enantioselectivities, which could only be obtained with moderate ee values in previous reports. These two efficient Friedel-Crafts alkylation processes feature low catalyst loading, broad functional group compatibilities, and the potential to provide practical pathways for the synthesis of enantioenriched bioactive triarylmethanes.

  DOI：

  10.1021/ol403680c