2-(diphenylphosphano)phenyl 6-fluorohexanoate | 1259882-11-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(diphenylphosphano)phenyl 6-fluorohexanoate
• 英文别名: (2-Diphenylphosphanylphenyl) 6-fluorohexanoate；(2-diphenylphosphanylphenyl) 6-fluorohexanoate
• CAS: 1259882-11-5
• 化学式: C₂₄H₂₄FO₂P
• 分子量: 394.426
• InChiKey: PGPUBPOFNBNNOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(3-叠氮丙基)生物素胺 、 2-(diphenylphosphano)phenyl 6-fluorohexanoate 以 水 、 乙腈 为溶剂， 以21%的产率得到6-fluoro-N-(3-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)propyl)hexanamide
  参考文献：
  名称：

  The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers

  摘要：

  The development of rapid radiolabeling techniques under mild reaction conditions involving the short-lived positron emitter fluorine-18 remains a special challenge in organic PET chemistry. This work describes a novel and facile application of the traceless Staudinger ligation as a mild and versatile labeling method for preparation of various radiotracers labeled with fluorine-18. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.134
• 作为产物：
  描述：

  2-(diphenylphosphano)phenyl 6-fluorohexanoate-borane 在 甲醇 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以99%的产率得到2-(diphenylphosphano)phenyl 6-fluorohexanoate
  参考文献：
  名称：

  The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers

  摘要：

  The development of rapid radiolabeling techniques under mild reaction conditions involving the short-lived positron emitter fluorine-18 remains a special challenge in organic PET chemistry. This work describes a novel and facile application of the traceless Staudinger ligation as a mild and versatile labeling method for preparation of various radiotracers labeled with fluorine-18. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.134

文献信息

• The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers
  作者：Marc Pretze、Frank Wuest、Tim Peppel、Martin Köckerling、Constantin Mamat

  DOI：10.1016/j.tetlet.2010.09.134

  日期：2010.12

  The development of rapid radiolabeling techniques under mild reaction conditions involving the short-lived positron emitter fluorine-18 remains a special challenge in organic PET chemistry. This work describes a novel and facile application of the traceless Staudinger ligation as a mild and versatile labeling method for preparation of various radiotracers labeled with fluorine-18. (C) 2010 Elsevier Ltd. All rights reserved.