3-bromo-1-[(2R)-3,3-dimethylbutan-2-yl]piperidine-2,4-dione | 1312415-09-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-bromo-1-[(2R)-3,3-dimethylbutan-2-yl]piperidine-2,4-dione
• CAS: 1312415-09-0
• 化学式: C₁₁H₁₈BrNO₂
• 分子量: 276.173
• InChiKey: SVFUWLABAMOGAU-YOXFSPIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
  申请人：MacDonald Gregor James

  公开号：US20120258955A1

  公开（公告）日：2012-10-11

  The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.
• US9040707B2
  申请人：——

  公开号：US9040707B2

  公开（公告）日：2015-05-26