NCG17 | 1079821-47-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: NCG17
• 英文别名: N-[(3-phenoxyphenyl)methyl]-4-[2-(2H-tetrazol-5-yl)ethyl]aniline
• CAS: 1079821-47-8
• 化学式: C₂₂H₂₁N₅O
• 分子量: 371.442
• InChiKey: OVWGFJDFVMHJNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  75.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• G-Protein-Conjugated Receptor Agonist
  申请人：Tsujimoto Gozoh

  公开号：US20110184031A1

  公开（公告）日：2011-07-28

  Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R 1 represents a C 1-6 alkyl group or the like; R 2 represents a hydrogen atom, a C 1-4 alkyl group or a C 1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR 3 — [wherein R 3 represents a hydrogen atom or a C 1-4 alkyl group].

  本发明揭示了一种新型的芳基羧酸化合物，其具有对GPR-120和/或GPR-40，特别是GPR-120的激动活性，因此可用作食欲调节剂、抗肥胖剂、糖尿病治疗剂、胰岛素分化细胞生长增强剂、代谢综合征治疗剂、胃肠疾病治疗剂、神经病治疗剂、精神障碍治疗剂、肺部疾病治疗剂、垂体激素分泌障碍治疗剂或脂肪调味/调料剂。芳基羧酸化合物由通式（I）表示。其中，环Q表示吡啶基或类似物；R1表示C1-6烷基或类似物；R2表示氢原子、C1-4烷基或C1-4烷氧基；m和n独立地表示1至5的整数；X表示氧原子、硫原子或-NR3- [其中R3表示氢原子或C1-4烷基]。
• G-PROTEIN-CONJUGATED RECEPTOR AGONIST
  申请人：Japan Science and Technology Agency

  公开号：EP2151236A1

  公开（公告）日：2010-02-10

  Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or - NR3- [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].

  本发明公开了一种新型芳烷基羧酸化合物，该化合物对 GPR-120 和/或 GPR-40（尤其是 GPR-120）具有激动活性，因此可用作食欲调节剂、抗肥胖剂、糖尿病治疗剂、胰腺β分化细胞生长促进剂、代谢综合征治疗剂、胃肠道疾病治疗剂、神经病治疗剂、精神疾病治疗剂、肺病治疗剂、垂体激素分泌紊乱治疗剂或脂质调味/调料剂。芳烷基羧酸化合物由通式 (I) 表示。(I) 其中环 Q 代表吡啶基或类似物；R1 代表 C1-6 烷基或类似物；R2 代表氢原子、C1-4 烷基或 C1-4 烷氧基；m 和 n 独立地代表 1 至 5 的整数；X 代表氧原子、硫原子或 - NR3-[其中 R3 代表氢原子或 C1-4 烷基]。
• US8318781B2
  申请人：——

  公开号：US8318781B2

  公开（公告）日：2012-11-27