3-(18F)fluoropropylamine | 1074712-85-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 3-(18F)fluoropropylamine
• 英文别名: 3-(18F)fluoranylpropan-1-amine
• CAS: 1074712-85-8
• 化学式: C₃H₈FN
• 分子量: 76.1032
• InChiKey: YTHVGJSPULXGNY-NUTRPMROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  5.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.02
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  3-(18F)fluoropropylamine 、 9H-β-carboline-3-carboxylic acid pentafluorophenyl ester 在 三乙胺 作用下， 生成 9Hβ-carboline 3-carboxylic acid 3-(18F)fluoropropylamide
  参考文献：
  名称：

  WO2008/132454

  摘要：

  公开号：
• 作为产物：
  描述：

  tert-butyl (3-(fluoro-18F)propyl)carbamate 在 盐酸 、 水 作用下， 以95%的产率得到3-(18F)fluoropropylamine
  参考文献：
  名称：

  WO2008/132454

  摘要：

  公开号：

文献信息

• Design, radiosynthesis, and evaluation of radiotracers for positron emission tomography imaging of stearoyl-CoA desaturase-1
  作者：William C. Silvers、Hancheng Cai、Orhan K. Öz、Xiankai Sun

  DOI：10.1016/j.bmcl.2015.12.062

  日期：2016.2

  Design, radiosynthesis, and biological evaluation of two radiotracers (N-(3-[F-18] fluoropropyl)-6-(4( trifluoromethyl) benzoyl)-piperazin-1-yl) pyridazine-3-carboxamide (F-18-FPPPT) and (N-(4-[ 18F] fluoroaniline)-6-(4-(trifluoromethyl) benzoyl)-piperazin-1-yl) pyridazine-3-carboxamide (F-18-FAPPT)) are described for noninvasive assessment of stearoyl-CoA desaturase-1 (SCD-1). The overexpression of SCD-1 in multiple solid tumors associates with poor survival in cancer patients. The two radiotracers, F-18-FPPPT and F-18-FAPPT, were each prepared in three steps in radiochemical yields of 21% and 3%, respectively. The practicality of imaging SCD-1 with F-18-FPPPT was tested in two mouse models bearing xenograft tumors with different levels of SCD-1 expression, which afforded a 1.8-fold uptake difference correspondingly. Our work indicates that it is possible to develop SCD-1 specific imaging probes from previously reported SCD-1 inhibitors. (C) 2015 Elsevier Ltd. All rights reserved.