N-{2-[N'-(2,2-diphenylethyl)]-aminoethyl}-decahydroquinoline | 627520-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{2-[N'-(2,2-diphenylethyl)]-aminoethyl}-decahydroquinoline
• 英文别名: 1(2H)-Quinolineethanamine, N-(2,2-diphenylethyl)octahydro-；N-[2-(3,4,4a,5,6,7,8,8a-octahydro-2H-quinolin-1-yl)ethyl]-2,2-diphenylethanamine
• CAS: 627520-82-5
• 化学式: C₂₅H₃₄N₂
• 分子量: 362.558
• InChiKey: XXFXEFXDORMING-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ANTI-TUBERCULAR DRUGS: COMPOSITIONS AND METHODS
  申请人：PROTOPOPOVA Marina Nikolaevna

  公开号：US20090192173A1

  公开（公告）日：2009-07-30

  Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis. In certain embodiments, the present invention comprises compositions comprising novel substituted ethylene diamine compounds further comprising antitubercular agents such as rifampicin, isoniazid, pyrazinamide and ethambutol.

  本发明提供了用于治疗由传染性病原体引起的疾病，特别是结核病的方法和组合物。具体而言，提供了用于治疗传染病的取代乙二胺的方法和组合物。在一个实施例中，这些方法和组合物用于治疗分枝杆菌感染，包括但不限于结核病。在某些实施例中，本发明包括包含新型取代乙二胺化合物的组合物，进一步包括抗结核药物如利福平、异烟肼、吡嗪酰胺和乙胺丁醇。
• ANTI TUBERCULAR DRUG: COMPOSITIONS AND METHODS
  申请人：Department of Health and Human Services

  公开号：EP1513825B1

  公开（公告）日：2016-10-05
• Compositions and methods for the treatment of infectious diseases
  申请人：PROTOPOPOVA Marina Nikolaevna

  公开号：US20110118307A1

  公开（公告）日：2011-05-19

  Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
• US7456222B2
  申请人：——

  公开号：US7456222B2

  公开（公告）日：2008-11-25
• US7842729B2
  申请人：——

  公开号：US7842729B2

  公开（公告）日：2010-11-30