6-chloro-3a,4,9,9a-tetrahydro-4,9-epoxynaphtho[2,3-c]furan-1,3-dione | 1251927-50-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 6-chloro-3a,4,9,9a-tetrahydro-4,9-epoxynaphtho[2,3-c]furan-1,3-dione
• CAS: 1251927-50-0
• 化学式: C₁₂H₇ClO₄
• 分子量: 250.638
• InChiKey: KDFIMCOHLOJJSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.78
• 重原子数：
  17.0
• 可旋转键数：
  0.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  6-chloro-3a,4,9,9a-tetrahydro-4,9-epoxynaphtho[2,3-c]furan-1,3-dione 在 盐酸 作用下， 以 甲醇 、 氯仿 为溶剂， 生成 6-chloro-2,3-naphthalenedicarboxylic anhydride
  参考文献：
  名称：

  Dual Fluorescent N-Aryl-2,3- naphthalimides: Applications in Ratiometric DNA Detection and White Organic Light-Emitting Devices

  摘要：

  A ten element matrix of 5- and 6-substituted-(2,3)-naphthalimides was prepared for the appropriate placement of substituents necessary to promote dual fluorescence (DF). As prescribed by our balanced seesaw photophysical model this matrix yielded nine new DF dyes out of a possible ten compounds. From this set of nine DF dyes, 4-fluoronaphthalic amide (37) was selected as a probe for ratiometric detection of DNA and demonstration of panchromatic emission.

  DOI：

  10.1021/ol101760m
• 作为产物：
  描述：

  马来酸酐 、 4-氯代苯酐 在 溶剂黄146 、 锌 、 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 反应 21.17h， 生成 6-chloro-3a,4,9,9a-tetrahydro-4,9-epoxynaphtho[2,3-c]furan-1,3-dione
  参考文献：
  名称：

  Dual Fluorescent N-Aryl-2,3- naphthalimides: Applications in Ratiometric DNA Detection and White Organic Light-Emitting Devices

  摘要：

  A ten element matrix of 5- and 6-substituted-(2,3)-naphthalimides was prepared for the appropriate placement of substituents necessary to promote dual fluorescence (DF). As prescribed by our balanced seesaw photophysical model this matrix yielded nine new DF dyes out of a possible ten compounds. From this set of nine DF dyes, 4-fluoronaphthalic amide (37) was selected as a probe for ratiometric detection of DNA and demonstration of panchromatic emission.

  DOI：

  10.1021/ol101760m