N-[3-(5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-nicotinamide hydrochloride | 1262855-52-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3-(5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-nicotinamide hydrochloride
• 英文别名: N-[3-(5-amino-3-methyl-2,6-dihydro-1,4-oxazin-3-yl)phenyl]pyridine-3-carboxamide;hydrochloride
• CAS: 1262855-52-6
• 化学式: C₁₇H₁₈N₄O₂*ClH
• 分子量: 346.816
• InChiKey: YMLSYNDUAVAKEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.36
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  89.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Badiger Sangamesh

  公开号：US20120302558A1

  公开（公告）日：2012-11-29

  The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.

  本发明涉及公式中所有变量均如规范所定义的新异环化合物，以自由形式或盐形式，以及它们的制备、医药用途和包含它们的药物。
• Oxazine Derivatives and their Use in the Treatment of Neurological Disorders
  申请人：HOLZER Philipp

  公开号：US20120238560A1

  公开（公告）日：2012-09-20

  The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.

  本发明涉及一种新型杂环化合物，其化学式为，在该式中，所有变量均如规范中定义，以自由形式或盐形式存在，以及它们的制备方法，医疗用途和包含它们的药物。
• OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Novartis AG

  公开号：EP2456763B1

  公开（公告）日：2015-01-21