meso-tetrakis(o-propionamidophenyl)porphyrin | 86727-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: meso-tetrakis(o-propionamidophenyl)porphyrin
• 英文别名: tetrakis(o-propionamidophenyl)porphyrin
• CAS: 86727-60-8；86782-66-3；86782-67-4；86782-68-5；125827-56-7
• 化学式: C₅₆H₅₀N₈O₄
• 分子量: 899.064
• InChiKey: HAQIAMKYUYMCQU-HUFIFTGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.72
• 重原子数：
  68.0
• 可旋转键数：
  12.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  173.76
• 氢给体数：
  6.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  nickel diacetate 、 meso-tetrakis(o-propionamidophenyl)porphyrin 以 甲醇 、 二氯甲烷 为溶剂， 生成 (cis 2,2)-Ni-tetrakis(o-propionamidophenyl)porphyrin
  参考文献：
  名称：

  栅栏卟啉，金属卟啉和二酸的热诱导和光诱导阻转异构化：检查卟啉溶液性质的方法

  摘要：

  DOI：

  10.1021/j100243a026
• 作为产物：
  描述：

  tetrakis-5,10,15,20-(o-aminophenyl)porphyrin 、 丙酰氯 在 吡啶 作用下， 以 苯 为溶剂， 生成 meso-tetrakis(o-propionamidophenyl)porphyrin
  参考文献：
  名称：

  Atropisomer-specific formation of premicellar porphyrin J-aggregates in aqueous surfactant solutions

  摘要：

  The 4,0-atropisomer of intermediate (C6 or C7) to long (C16) chain length picket fence porphyrins (PFPs) exhibit red-shifted absorption and reduced singlet and triplet lifetimes in dilute aqueous surfactant solutions (i.e. below the critical micelle concentration). The spectral and photophysical behavior of these species is consistent with formation of premicellar aggregates containing two or more porphyrin chromophores lying in an offset, face-to-face arrangement (lambda-max approximately 436 nm, v sharp, for C6 or C7 compounds), which differ from normal aqueous porphyrin aggregates (lambda-max approximately 426 nm, broad) or monomeric porphyrin in homogeneous or micellar solution (lambda-max = 418-420 nm, sharp). The most characteristic behavior is noted at intermediate chain lengths for the free base or Pd(II) complex of 4,0-meso-tetrakis(2-hexanamidophenyl)porphyrin (4,0-THex) and for the free base of 4,0-THept, suggesting an optimal molecular hydrophobicity, side-chain length, and molecular topology for complex formation. The premicellar surfactant-porphyrin complexes are formed selectively from the 4,0-atropisomer and exhibit an SDS/porphyrin ratio of 3.2 for 4,0-THex. Acid-base titration behavior of the 4,0-THex J-aggregates suggests a structure in which the porphyrin core is isolated from the anionic surfactant head groups in a relatively hydrophobic microenvironment. Addition of alcohols or surfactant to disorganized aqueous aggregates of short- and long-chain 4,0-PFPs, respectively, apparently results in a modest reorganization of porphyrin chromophores (lambda-max approximately 436-438 nm) indicative of an inherent tendency toward J-aggregation for the 4,0-isomer.

  DOI：

  10.1021/j100163a035

文献信息

• PHOTOACTIVATABLE ANTIMICROBIAL AGENTS AND THERAPEUTIC AND DIAGNOSTIC METHODS OF USING SAME
  申请人：Hasan Tayyaba

  公开号：US20110112059A1

  公开（公告）日：2011-05-12

  The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.

  本发明提供了用于检测β-内酰胺酶活性的光敏剂化合物。利用本发明的光敏剂化合物进行微生物β-内酰胺酶的检测、定量和分类或分型的方法和试剂盒。
• [EN] beta-LACTAMASE TARGETED PHOTOSENSITIZER FOR PESTICIDE AND PEST DETECTION<br/>[FR] PHOTOSENSIBILISATEUR CIBLÉ PAR LA Beta-LACTAMASE POUR PESTICIDE ET DÉTECTION D'ORGANISMES NUISIBLES
  申请人：GEN HOSPITAL CORP

  公开号：WO2013192521A1

  公开（公告）日：2013-12-27

  Photoactivatable pesticide compounds and methods for the use thereof in the elimination and detection of pests are provided.

  提供了用于消灭和检测害虫的光活化杀虫剂化合物及其使用方法。
• COMPOSITIONS AND METHODS FOR PRESERVING PLATELET FUNCTION
  申请人：BIOVEC TRANSFUSION, LLC

  公开号：US20150056604A1

  公开（公告）日：2015-02-26

  Compositions and methods for maintaining platelet functionality and extending the shelf-life of platelets are described. Platelet preservation compositions include a photosensitizer and a plurality of platelet preservation agents. A method for preserving platelets and extending their shelf-life includes irradiating a platelet mixture containing a photosensitizer under conditions sufficient to activate the photosensitizer and inactivate microbes in the platelet mixture to form a microbe-depleted platelet preparation. A plurality of platelet preservation agents are added to the microbe-depleted platelet preparation for extending the platelet shelf-life. Prior to transfusion, the photosensitizer and platelet preservation agents can be removed by diafiltration and/or the use of compound adsorption devices.

  本文描述了维持血小板功能和延长血小板货架寿命的组合物和方法。血小板保存组合物包括光敏剂和多种血小板保存剂。一种保存血小板并延长其货架寿命的方法包括在足以激活光敏剂并灭活血小板混合物中的微生物的条件下，照射含有光敏剂的血小板混合物，以形成去除微生物的血小板制备物。在延长血小板货架寿命之前，向去除微生物的血小板制备物中添加多种血小板保存剂。在输血之前，可以通过透析和/或使用化合物吸附装置去除光敏剂和血小板保存剂。
• Myeloid cell-specific lectin
  申请人：Crucell Holland B.V.

  公开号：EP2322547A1

  公开（公告）日：2011-05-18

  The present invention provides a human C-type lectin, binding molecules that specifically bind to the human C-type lectin, nucleic acid molecules encoding the binding molecules or the human C-type lectin, compositions comprising the binding molecules or the human C-type lectin and methods of identifying or producing the binding molecules. The human C-type lectin is specifically expressed on myeloid cells and binding molecules capable of specifically binding to the human C-type lectin can be used in the diagnosis, prevention and/or treatment of neoplastic disorders and diseases.

  本发明提供了一种人C型凝集素、与人C型凝集素特异性结合的结合分子、编码结合分子或人C型凝集素的核酸分子、包含结合分子或人C型凝集素的组合物以及鉴定或生产结合分子的方法。人 C 型凝集素特异性地表达在髓细胞上，能与人 C 型凝集素特异性结合的结合分子可用于诊断、预防和/或治疗肿瘤性紊乱和疾病。
• BODIPY-LABELLED ENZYME SUBSTRATES AND METHODS USING THEM
  申请人：The General Hospital Corporation

  公开号：EP3056497A1

  公开（公告）日：2016-08-17

  The present invention provides photosensitizer compounds for use in detecting betalactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of quantitation of and classification or typing of microbial beta-lactamases.

  本发明提供了用于检测β-内酰胺酶活性的光敏剂化合物。利用本发明的光敏剂化合物对微生物 beta-内酰胺酶进行定量检测、分类或分型的方法和试剂盒。