5-(2-morpholin-4-ylethyl)-2-pyridin-2-yl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | 1010860-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(2-morpholin-4-ylethyl)-2-pyridin-2-yl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
• 英文别名: 5-[2-(morpholin-4-yl)ethyl]-2-(pyridin-2-yl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione；5-(2-morpholin-4-ylethyl)-2-pyridin-2-yl-1H-pyrazolo[4,3-c]pyridine-3,6-dione
• CAS: 1010860-82-8
• 化学式: C₁₇H₁₉N₅O₃
• 分子量: 341.37
• InChiKey: DTMJLSYMVBVNOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  78
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS
  申请人：Page Patrick

  公开号：US20100048560A1

  公开（公告）日：2010-02-25

  The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式(I)的吡唑吡啶衍生物、其制药组合物以及它们用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸酰化酶（NADPH氧化酶）相关的疾病或症状的用途。
• Pyrazolo Pyridine Derivatives as NADPH Oxidase Inhibitors
  申请人：Genkyotex Sa

  公开号：US20130123256A1

  公开（公告）日：2013-05-16

  The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的吡唑吡啶衍生物，其制药组合物以及它们用于治疗和/或预防与尼克酰胺腺嘌呤二核苷酸磷酸酰化酶（NADPH氧化酶）相关的疾病或症状的用途。
• Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
  申请人：GENKYOTEX SA

  公开号：EP2545918A1

  公开（公告）日：2013-01-16

  The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的吡唑并吡啶衍生物、其药物组合物及其用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH 氧化酶）有关的紊乱或病症。
• BIODEGRADABLE ELASTOMERS PREPARED BY THE CONDENSATION OF AN ORGANIC DI-, TRI- OR TETRA-CARBOXYLIC ACID AND AN ORGANIC DIOL
  申请人：Younes Husam

  公开号：US20100204432A1

  公开（公告）日：2010-08-12

  The present disclosure relates to biodegradable and biocompatible elastomeric polymers prepared by the condensation of an organic di-, tri- or tetra-carboxylic acid and an organic diol followed by thermal crosslinking with a bis- or tri-lactone or reaction with a photosensitive compound and subsequent photocrosslinking. Said elastomers are amorphous, have a glass transition temperature below both room temperature and body temperature and will homogeneously degrade to water soluble by-products with no reported toxicity.
• US8389518B2
  申请人：——

  公开号：US8389518B2

  公开（公告）日：2013-03-05