1,2-Anthracenediol, 9-(hydroxymethyl)-10-methyl- | 496783-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,2-Anthracenediol, 9-(hydroxymethyl)-10-methyl-
• 英文别名: 9-(hydroxymethyl)-10-methylanthracene-1,2-diol
• CAS: 496783-15-4
• 化学式: C₁₆H₁₄O₃
• 分子量: 254.28
• InChiKey: CHKWZBTWGTVPHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Antigenic GM-CSF peptides and antibodies to GM-CSF
  申请人：Morphotek, Inc.

  公开号：US10023632B2

  公开（公告）日：2018-07-17

  Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided. The antibodies may be used in therapeutic methods, for example in the treatment of cancer, infectious disease, or autoimmune disease.

  提供了能分泌具有高结合特异性和生物活性（特别是对粒细胞-巨噬细胞集落刺激因子的中和活性）的人类单克隆抗体的杂交瘤系，以及产生杂交瘤系的方法。还提供了目标抗原和表位。这些抗体可用于治疗方法，例如治疗癌症、传染病或自身免疫性疾病。
• Methods for generating antibiotic resistant microbes and novel antibiotics
  申请人：——

  公开号：US20030068808A1

  公开（公告）日：2003-04-10

  The invention provides methods for generating antibiotic resistant bacteria comprising blocking mismatch repair in a bacterium to make hypermutable bacteria, contacting the bacteria with at least one antibiotic, selecting bacteria that are resistant to the antibiotic, and culturing the antibiotic resistant bacteria. The invention also provides methods of determining the genes responsible for antibiotic resistance.

  本发明提供了产生抗生素耐药细菌的方法，包括阻断细菌中的错配修复以制造高耐药细菌，使细菌与至少一种抗生素接触，选择对抗生素耐药的细菌，培养抗生素耐药细菌。本发明还提供了确定抗生素耐药性基因的方法。
• Chemical inhibitors of mismatch repair
  申请人：——

  公开号：US20030091997A1

  公开（公告）日：2003-05-15

  Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. Methods of generating mutations in genes of interest and of making various cells mismatch repair defective through the use of chemicals to block mismatch repair in in vivo are disclosed.

  人类错配修复基因的显性负等位基因可用于产生超变异细胞和生物。通过将这些基因引入细胞和转基因动物，可以比依靠自然突变率更有效地制备出具有新颖和有用特性的新细胞系和动物品种。本文公开了在相关基因中产生突变的方法，以及通过使用化学物质阻断体内错配修复使各种细胞产生错配修复缺陷的方法。
• Genetic hypermutability of plants for gene discovery and diagnosis
  申请人：——

  公开号：US20030143586A1

  公开（公告）日：2003-07-31

  The invention provides methods for identifying polymorphic markers for herbicide resistance in weeds and for generating herbicide susceptible and herbicide resistant weeds by mutagenizing weeds and comparing genetic differences between herbicide resistant and herbicide susceptible weeds. The methods may involve the inhibition of mismatch repair in the weeds through the introduction of dominant negative alleles of mismatch repair genes, through T-DNA insertional mutations, or the use of chemical inhibitors of mismatch repair. The invention also provides polymorphic markers of herbicide resistance and methods and kits to screen for herbicide resistant weeds, such as horseweed, goosegrass and rye grass.

  本发明提供了通过诱变杂草和比较抗除草剂杂草与抗除草剂杂草之间的遗传差异来鉴定杂草中抗除草剂的多态性标记和产生易受除草剂影响的杂草和抗除草剂杂草的方法。这些方法可以通过引入错配修复基因的显性负等位基因、T-DNA 插入突变或使用错配修复化学抑制剂来抑制杂草的错配修复。本发明还提供了除草剂抗性的多态性标记，以及筛选抗除草剂杂草（如马草、鹅掌柴和黑麦草）的方法和试剂盒。
• Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
  申请人：——

  公开号：US20040214288A1

  公开（公告）日：2004-10-28

  The invention provides methods for generating high titers of high-affinity antibodies from hybridoma cells produced by fusing myeloma cells with in vitro immunized donor cells. The hybridoma cells or mammalian expression cells with cloned antibody genes from the hybridomas producing the high-affinity antibodies may be mismatch repair defective due to defects of endogenous mismatch repair subunits of through expression of a dominant negative allele of a mismatch repair gene which allows the hybridoma cell to be hypermutable, may be rendered hypermutable by chemical means, or may be naturally mismatch repair deficient. High-affinity antibodies and high titer producer cells producing antibodies may be prepared by the methods of the invention.

  本发明提供了利用骨髓瘤细胞与体外免疫供体细胞融合产生的杂交瘤细胞产生高滴度高亲和力抗体的方法。产生高亲和力抗体的杂交瘤细胞或带有克隆抗体基因的哺乳动物表达细胞，可能由于内源性错配修复亚基的缺陷而存在错配修复缺陷，或由于表达了错配修复基因的显性阴性等位基因而使杂交瘤细胞具有高突变性，或通过化学方法使杂交瘤细胞具有高突变性，或可能天然存在错配修复缺陷。用本发明的方法可以制备高亲和力抗体和产生抗体的高滴度生产细胞。