Propanol, 1(or 2)-(2-hydroxymethylethoxy)-, monobenzoate | 32686-95-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Propanol, 1(or 2)-(2-hydroxymethylethoxy)-, monobenzoate
• 英文别名: benzoic acid;2-(2-hydroxypropoxy)propan-1-ol
• CAS: 32686-95-6
• 化学式: C13H20O5
• 分子量: 256.29
• InChiKey: VVKREWPWSWPBGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.15
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS COMPRISING TRITERPENOIDS AND USES THEREOF FOR TREATING OPTIC NEUROPATHY<br/>[FR] COMPOSITIONS COMPRENANT DES TRITERPÉNOÏDES ET LEURS UTILISATIONS POUR TRAITER UNE NEUROPATHIE OPTIQUE
  申请人：REGENERA PHARMA LTD

  公开号：WO2018047175A1

  公开（公告）日：2018-03-15

  The invention relates to compositions and formulations comprising at least one triterpenoic acid and at least one neutral triterpenoid and uses thereof for treating optic neuropathy conditions.

  该发明涉及包含至少一种三萜酸和至少一种中性三萜类化合物的组合物和配方，以及用于治疗视神经病症的用途。
• [EN] COMPOSITIONS COMPRISING TRITERPENOIDS<br/>[FR] COMPOSITIONS COMPRENANT DES TRITERPÉNOÏDES
  申请人：REGENERA PHARMA LTD

  公开号：WO2017051423A1

  公开（公告）日：2017-03-30

  The invention relates to compositions and formulations comprising at least one triterpenoic acid and at least one neutral triterpenoid and uses thereof for treating for use in treating a condition selected from Alzheimer's disease (AD), Parkinson's Diseases (PD) and vascular dementia (VD).

  该发明涉及包含至少一种三萜酸和至少一种中性三萜类化合物的组合物和配方，以及它们用于治疗阿尔茨海默病（AD）、帕金森病（PD）和血管性痴呆（VD）等疾病的用途。
• [EN] COMPOSITIONS COMPRISING ACIDIC EXTRACTS OF MASTIC GUM AND USES THEREOF FOR TREATING OPTIC NEUROPATHY<br/>[FR] COMPOSITIONS COMPRENANT DES EXTRAITS ACIDES DE GOMME DE MASTIC ET LEURS UTILISATIONS POUR TRAITER UNE NEUROPATHIE OPTIQUE
  申请人：REGENERA PHARMA LTD

  公开号：WO2018047176A1

  公开（公告）日：2018-03-15

  The invention relates to compositions and formulations comprising isolated acidic fraction of mastic gum and uses thereof for treating optic neuropathy conditions.

  该发明涉及包含分离的松香酸性部分的组合物和配方，以及用于治疗视神经病症的用途。
• INTEGRATED PROCESS FOR THE PRODUCTION OF BENZOATE PLASTICIZERS
  申请人：Eastman Chemical Company

  公开号：US20160068655A1

  公开（公告）日：2016-03-10

  The invention relates to a process that integrates the oxidation of toluene to benzoic acid with the production of benzoate plasticizers. Toluene is fed to an oxidation vessel in the presence of oxygen and an oxidation catalyst wherein benzoic acid serves as the solvent for the oxidation. The crude benzoic acid produced is not purified and is then reacted with an alcohol in the presence of an esterification catalyst to produce the crude benzoate ester. The oxidation catalyst, esterification catalyst, and other impurities can be mostly removed from the crude benzoate ester in subsequent washing and filtering steps. The benzoate esters produced through this method can be made in fewer steps with both yields and purities above 80%.

  该发明涉及一种将甲苯氧化为苯甲酸并生产苯甲酸酯类可塑剂的过程。将甲苯与氧气和氧化催化剂一起加入氧化反应器中，其中苯甲酸作为氧化溶剂。产生的粗苯甲酸不进行纯化，然后在酯化催化剂的存在下与醇反应，生成粗苯甲酸酯。在随后的洗涤和过滤步骤中，可以从粗苯甲酸酯中去除大部分氧化催化剂、酯化催化剂和其他杂质。通过这种方法生产的苯甲酸酯可以在较少的步骤中制得，并且产率和纯度均可达到80%以上。
• [EN] METHOD FOR PREPARING BENZOIC ACID ESTERS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'ESTERS D'ACIDE BENZOÏQUE
  申请人：SIBUR HOLDING PUBLIC JOINT STOCK CO

  公开号：WO2019059801A1

  公开（公告）日：2019-03-28

  The invention relates to the method of preparing benzoic acid esters which provides high selectivity of the process, and high yield of the desired product, as well as the reduction of the duration of the esterification process, comprising esterification of benzoic acid with monohydric alcohols having a number of carbon atoms from 6 to 12, or polyhydric alcohols having a number of carbon atoms from 2 to 10, in the presence of metal containing catalyst in the media of aromatic solvent at the stepwise buildup of the temperature of the process to 180-200°C, further to 200-220°C, and then to 240-250°C.

  本发明涉及制备苯甲酸酯的方法，该方法提供了高选择性的过程和高产率的所需产品，同时减少了酯化过程的持续时间，包括在芳香溶剂介质中，使用含金属催化剂，在温度逐步升高到180-200°C，进一步升高到200-220°C，然后升高到240-250°C的情况下，将苯甲酸与碳原子数为6-12的单元醇或碳原子数为2-10的多元醇酯化。