(2S)-2-{4-{(E)-[(benzyloxy)imino]methyl}-2-chloro-5-[(1,3,4-trimethyl-1H-pyrazol-5-yl)oxy]phenoxy}propionic acid | 1043916-73-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-{4-{(E)-[(benzyloxy)imino]methyl}-2-chloro-5-[(1,3,4-trimethyl-1H-pyrazol-5-yl)oxy]phenoxy}propionic acid
• 英文别名: (2S)-2-[2-chloro-4-[(E)-phenylmethoxyiminomethyl]-5-(2,4,5-trimethylpyrazol-3-yl)oxyphenoxy]propanoic acid
• CAS: 1043916-73-9
• 化学式: C₂₃H₂₄ClN₃O₅
• 分子量: 457.914
• InChiKey: ISNANJLHJNUGGL-YEEYNWEUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  95.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• PYRAZOLE COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2128138A1

  公开（公告）日：2009-12-02

  The present invention aims to provide an agent for the prophylaxis or treatment of diabetes, which has a superior hypoglycemic action, and is associated with a fewer side effects such as body weight gain and the like. The present invention relates to an agent for the prophylaxis or treatment of diabetes comprising a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof.

  本发明旨在提供一种用于预防或治疗糖尿病的药物，具有优越的降血糖作用，并且与较少的副作用，如体重增加等相关。本发明涉及一种用于预防或治疗糖尿病的药物，包括由以下式表示的化合物：其中每个符号如描述中所定义，或其盐，或其前药。
• Novel Heterocyclic Compounds
  申请人：Srinivas Akella Satya Surya Visweswara

  公开号：US20100152188A1

  公开（公告）日：2010-06-17

  The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their stereoisomers, their pharmaceutically acceptable salts and compositions. The present invention more particularly provides novel heterocyclic compounds of the general formula (I).

  本发明涉及一般式(I)的新化合物，它们的衍生物、类似物、立体异构体、药学上可接受的盐和组合物。本发明更特别地提供一般式(I)的新杂环化合物。