[2-(4-Hydroxy-benzo[1,3]dioxol-5-ylmethyl)-pyrrolidin-1-yl]-(4-hydroxy-3,5-dimethoxy-phenyl)-methanone | 302969-03-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: [2-(4-Hydroxy-benzo[1,3]dioxol-5-ylmethyl)-pyrrolidin-1-yl]-(4-hydroxy-3,5-dimethoxy-phenyl)-methanone
• CAS: 302969-03-5
• 化学式: C₂₁H₂₃NO₇
• 分子量: 401.416
• InChiKey: GXSLQMFXDLDKOO-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  [2-(4-Hydroxy-benzo[1,3]dioxol-5-ylmethyl)-pyrrolidin-1-yl]-(4-hydroxy-3,5-dimethoxy-phenyl)-methanone 在 氢氧化钾 、 三氯氧磷 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 6.0h， 生成 (5S,8aS)-10-Benzyloxy-5-(4-benzyloxy-3,5-dimethoxy-phenyl)-5,6,7,8,8a,9-hexahydro-1,3-dioxa-5a-aza-dicyclopenta[b,g]naphthalene
  参考文献：
  名称：

  First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin

  摘要：

  The benzoindolizidine and-quinolizidine analogues of alpha- and beta-peltatin were designed and synthesized by two different synthetic routes involving as the key step the Bischler-Napieralski cyclization of suitably substituted N-acyl-2-arylmethylpyrrolidine and -piperidine derivatives. The in vitro biological activity of these analogues as well as some of their derivatives was subsequently evaluated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00130-9
• 作为产物：
  描述：

  {2-[1-(4-Benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-pyrrolidin-1-yl}-(4-benzyloxy-3,5-dimethoxy-phenyl)-methanone 在 palladium on activated charcoal 甲酸铵 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 以87%的产率得到[2-(4-Hydroxy-benzo[1,3]dioxol-5-ylmethyl)-pyrrolidin-1-yl]-(4-hydroxy-3,5-dimethoxy-phenyl)-methanone
  参考文献：
  名称：

  First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin

  摘要：

  The benzoindolizidine and-quinolizidine analogues of alpha- and beta-peltatin were designed and synthesized by two different synthetic routes involving as the key step the Bischler-Napieralski cyclization of suitably substituted N-acyl-2-arylmethylpyrrolidine and -piperidine derivatives. The in vitro biological activity of these analogues as well as some of their derivatives was subsequently evaluated. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00130-9